Suggested Autism Candidate Gene List
- This dataset contains 171 genes.
- Using a Core Dataset from review papers, we get a weight matrix.
- The comobined score comes from scores from each dataset plus each weight matrix. The higher the score, the more confident the gene is.
- Only the genes with total score larger than or equal to 16 (the smallest score of the gene in the core datasset) and level3/level 4 syndromic autism genes are listed below. (More information about the dataset)
| Gene ID | Gene Symbol | Band | Evidence Score | Total Score | |||||
|---|---|---|---|---|---|---|---|---|---|
| GWAS | Expression | CNV | Linkage | Low-Scale Association | Other Low-Scale Studies | ||||
| AutG5649 | RELN | 7q22 | 2 | 0 | 0 | 1 | 3 | 3 | 43 |
| AutG26047 | CNTNAP2 | 7q35 | 2 | 0 | 1 | 1 | 2 | 3 | 42 |
| AutG5021 | OXTR | 3p25 | 1 | 1 | 1 | 1 | 3 | 3 | 40 |
| AutG57502 | NLGN4X | Xp22.33 | 2 | 0 | 1 | 0 | 1 | 3 | 38 |
| AutG2562 | GABRB3 | 15q11.2-q12 | 0 | 1 | 3 | 0 | 2 | 3 | 34 |
| AutG721 | C4B | 6p21.3 | 0 | 2 | 1 | 0 | 3 | 3 | 34 |
| AutG4233 | MET | 7q31 | 0 | 1 | 1 | 0 | 3 | 3 | 33 |
| AutG93986 | FOXP2 | 7q31 | 1 | 0 | 1 | 1 | 1 | 3 | 33 |
| AutG3123 | HLA-DRB1 | 6p21.3 | 0 | 1 | 1 | 0 | 3 | 3 | 33 |
| AutG6532 | SLC6A4 | 17q11.2 | 0 | 0 | 0 | 2 | 3 | 3 | 32 |
| AutG54715 | RBFOX1 | 16p13.3 | 2 | 2 | 1 | 2 | 0 | 2 | 32 |
| AutG2020 | EN2 | 7q36 | 0 | 0 | 0 | 0 | 3 | 3 | 30 |
| AutG627 | BDNF | 11p13 | 0 | 0 | 1 | 0 | 2 | 3 | 29 |
| AutG9378 | NRXN1 | 2p16.3 | 0 | 0 | 2 | 0 | 1 | 3 | 28 |
| AutG4139 | MARK1 | 1q41 | 0 | 1 | 0 | 0 | 2 | 3 | 28 |
| AutG8604 | SLC25A12 | 2q24 | 0 | 2 | 0 | 2 | 3 | 2 | 27 |
| AutG26470 | SEZ6L2 | 16p11.2 | 0 | 0 | 3 | 0 | 0 | 3 | 27 |
| AutG5595 | MAPK3 | 16p11.2 | 0 | 0 | 3 | 0 | 0 | 3 | 27 |
| AutG54413 | NLGN3 | Xq13.1 | 0 | 0 | 1 | 0 | 1 | 3 | 26 |
| AutG438 | ASMT | Xp22.3 or Yp11.3 | 0 | 0 | 1 | 0 | 1 | 3 | 26 |
