AutismKB


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Enriched Pathway

The pathway-enriched analysis was done by KOBAS2.0 using 171 confident genes, including the ranked non-syndromic genes (Score>=18) and level 3/4 syndromic genes.(Cutoff of enriched pathway: P <= 1.00e-2)
Statistic method: hypergeometric test
FDR correction method: Benjamini and Hochberg (1995)
KEGG PATHWAYReactomeBioCycPID BioCartaPID CuratedPID Reactome
KEGG PATHWAY
TermIDSample NumberBackgroud NumberP ValueCorrected P ValueGenes
Serotonergic synapse hsa04726 15 122 2.50E-5 1.56E-3
775 | 4128 | 5595 | 5594 | 5579 | 3751 | 2560 | 2562 | 778 | 673 | 3265 | 5604 | 6532 | 5613 | 3845 |
Long-term potentiation hsa04720 11 70 3.06E-5 1.70E-3
775 | 5595 | 5594 | 5579 | 5613 | 673 | 5604 | 6197 | 3845 | 3265 | 1387 |
Retrograde endocannabinoid signaling hsa04723 12 99 1.82E-4 7.14E-3
775 | 5595 | 5594 | 5579 | 2557 | 2558 | 2560 | 2562 | 778 | 2567 | 2892 | 5613 |
Reactome
TermIDSample NumberBackgroud NumberP ValueCorrected P ValueGenes
Neuronal System REACT:13685 21 278 6.47E-8 7.71E-6
5594 | 777 | 1141 | 1312 | 5579 | 2557 | 2558 | 2560 | 3778 | 1137 | 6197 | 2567 | 2892 | 3751 | 4128 | 3265 | 2562 | 673 | 2571 | 7915 | 2898 |
Developmental Biology REACT:111045 21 392 1.69E-5 1.28E-3
775 | 5595 | 1641 | 5594 | 6326 | 3690 | 4233 | 778 | 7204 | 3265 | 5604 | 4208 | 6197 | 6323 | 9037 | 8128 | 3845 | 1387 | 9968 | 3897 | 5781 |
BioCyc
TermIDSample NumberBackgroud NumberP ValueCorrected P ValueGenes
MAP kinase cascade PWY66-14 3 6 2.37E-4 8.37E-3
5604 | 5595 | 5594 |
PID BioCarta
TermIDSample NumberBackgroud NumberP ValueCorrected P ValueGenes
PID Curated
TermIDSample NumberBackgroud NumberP ValueCorrected P ValueGenes
Ras signaling in the CD4+ TCR pathway tcrraspathway 5 11 8.05E-5 3.71E-3
5604 | 5595 | 5594 | 5579 | 673 |
PID Reactome
TermIDSample NumberBackgroud NumberP ValueCorrected P ValueGenes
Signal transduction by L1 500100 4 13 1.40E-4 5.94E-3
5604 | 5595 | 5594 | 3897 |

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  (e.g. NLGN4X)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 616
  • Genes: 3,075
  • SNPs/VNTRs: 3,386
  • CNVs: 4,617
  • Linkage Regions: 158
  • Last Update: 05/25/2012
  • Click to Download Data

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