Enriched Pathway

The pathway-enriched analysis was done by KOBAS2.0 using 171 confident genes, including the ranked non-syndromic genes (Score>=18) and level 3/4 syndromic genes.(Cutoff of enriched pathway: P <= 1.00e-2)

Statistic method: hypergeometric test

FDR correction method: Benjamini and Hochberg (1995)

KEGG PATHWAY

KEGG PATHWAY

Term	ID	Sample Number	Backgroud Number	P Value	Corrected P Value
Serotonergic synapse	hsa04726	15	122	2.50E-5	1.56E-3
775 \| 4128 \| 5595 \| 5594 \| 5579 \| 3751 \| 2560 \| 2562 \| 778 \| 673 \| 3265 \| 5604 \| 6532 \| 5613 \| 3845 \|
Long-term potentiation	hsa04720	11	70	3.06E-5	1.70E-3
775 \| 5595 \| 5594 \| 5579 \| 5613 \| 673 \| 5604 \| 6197 \| 3845 \| 3265 \| 1387 \|
Retrograde endocannabinoid signaling	hsa04723	12	99	1.82E-4	7.14E-3
775 \| 5595 \| 5594 \| 5579 \| 2557 \| 2558 \| 2560 \| 2562 \| 778 \| 2567 \| 2892 \| 5613 \|

Reactome

Term	ID	Sample Number	Backgroud Number	P Value	Corrected P Value
Neuronal System	REACT:13685	21	278	6.47E-8	7.71E-6
5594 \| 777 \| 1141 \| 1312 \| 5579 \| 2557 \| 2558 \| 2560 \| 3778 \| 1137 \| 6197 \| 2567 \| 2892 \| 3751 \| 4128 \| 3265 \| 2562 \| 673 \| 2571 \| 7915 \| 2898 \|
Developmental Biology	REACT:111045	21	392	1.69E-5	1.28E-3
775 \| 5595 \| 1641 \| 5594 \| 6326 \| 3690 \| 4233 \| 778 \| 7204 \| 3265 \| 5604 \| 4208 \| 6197 \| 6323 \| 9037 \| 8128 \| 3845 \| 1387 \| 9968 \| 3897 \| 5781 \|

BioCyc

Term	ID	Sample Number	Backgroud Number	P Value	Corrected P Value	Genes
MAP kinase cascade	PWY66-14	3	6	2.37E-4	8.37E-3
5604 \| 5595 \| 5594 \|

PID BioCarta

Term	ID	Sample Number	Backgroud Number	P Value	Corrected P Value	Genes

PID Curated

Term	ID	Sample Number	Backgroud Number	P Value	Corrected P Value	Genes
Ras signaling in the CD4+ TCR pathway	tcrraspathway	5	11	8.05E-5	3.71E-3
5604 \| 5595 \| 5594 \| 5579 \| 673 \|

PID Reactome

Term	ID	Sample Number	Backgroud Number	P Value	Corrected P Value	Genes
Signal transduction by L1	500100	4	13	1.40E-4	5.94E-3
5604 \| 5595 \| 5594 \| 3897 \|

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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

Studies: 616
Genes: 3,075
SNPs/VNTRs: 3,386
CNVs: 4,617
Linkage Regions: 158
Last Update: 05/25/2012
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