AutismKB

Evidence Detail for CLIC3


View Evidences View Annotations
Basic Information Top
Gene Symbol:CLIC3 ( - )
Gene Full Name: chloride intracellular channel 3
Band: 9q34.3
Quick LinksEntrez ID:9022; OMIM: 606533; Uniprot ID:CLIC3_HUMAN; ENSEMBL ID: ENSG00000169583
Sequences Top
>CLIC3|9022|nucleotide
Show »

>CLIC3|9022|protein
Show »

Evidence Statistic Top

Click the link of the category-specific score to view different category of evidences. The categories without any evidences are hidden by default.
Evidences Syndromic Gene GWAS Expression CNV Linkage Low Scale Association Other Studies Total
Score (No. of Studies) No 0 (0) 2 (2) 1 (2) 1 (3) 0 (0) 0 (0) 5 (5)
Syndromic Autism Gene Top
Low Scale Association Studies (by Ethnic Group) Top
Genome-Wide Association Studies(By Ethnic Group) Top
Other Low Scale Gene Studies Top
Large Scale Expression Studies Top
Microarray Studies: 2
Reference Population Tissue #Subjects
(% Women)
ADI-R ADOS Endo- pheno Diagnosis Normal Controls
(% Women)
Fold Change Up/ Down P/Q value
Gregg, 2008_1 mixed lymphoblastoid cell lines 35
(14.29%)
autismautism 12
(25.00%)
2.222 Up 0.0217
  • Platform: U133 Plus 2.0 GeneChip (Affymetrix,Santa Clara, CA, USA)
  • ProbeSet: 219529_at
  • RefSeq_ID/ EST: NM_004669
  • GEO_ID: GSE6575
  • Statistic Method: a stringent 1.5-fold unpaired t test with Benjamini
Gregg, 2008_2 mixed lymphoblastoid cell lines 17
(11.76%)
autism with early onset autism 12
(25.00%)
2.176 Up 0.0375
  • Platform: U133 Plus 2.0 GeneChip (Affymetrix,Santa Clara, CA, USA)
  • ProbeSet: 219529_at
  • RefSeq_ID/ EST: NM_004669
  • GEO_ID: GSE6575
  • Statistic Method: a stringent 1.5-fold unpaired t test with Benjamini
Proteomics Studies:0
Reference Population Tissue Platform #Subjects
(% Women)
ADI-R ADOS Diagnosis Normal Controls(% Women)
No Evidence.
CNV Studies Top
CNV Name Chr Band Gain/Loss Number of CNVs Evidence Type Reference
Case Control
AutCNV0000550 9 9q34.13-34.3 Loss 1 - Overlapping/Recurrent CNVs; Gregory, 2009
AutCNV0001422 9 9q34.3 gain 1 - Potential_DeNovo Pinto, 2010
AutCNV0001423 9 9q34.3 gain 1 - Potential_DeNovo Pinto, 2010
AutCNV0002271 9 9q34.3 gain 1 - na Pinto, 2010
AutCNV0002742 9 9q34.3 gain 1 - maternal Pinto, 2010
Linkage Studies Top
Linkage Name Band Chr Marker LOD NPL P_Value Reference
AutLD0000033 9q34.3 9 D9S1826 1.46 - - Monaco, 2001
AutLD0000075 9q34.3 9 D9S158 1.66 - - Buxbaum, 2001
AutLD0000079 9q34.3 9 D9S158/D9S905 1.67 - - Lamb, 2005

Contact Us if you are an author of a study regarding this gene and do not find your study in this table or find errors in the representation of your study details.

Quick Search:


  (e.g. NLGN4X)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 616
  • Genes: 3,075
  • SNPs/VNTRs: 3,386
  • CNVs: 4,617
  • Linkage Regions: 158
  • Last Update: 05/25/2012
  • Click to Download Data

Registered with NIF