AutismKB

Evidence Detail for VARS


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Basic Information Top
Gene Symbol:VARS ( G7A,VARS1,VARS2 )
Gene Full Name: valyl-tRNA synthetase
Band: 6p21.3
Quick LinksEntrez ID:7407; OMIM: 192150; Uniprot ID:SYVC_HUMAN; ENSEMBL ID: ENSG00000204394
Sequences Top
>VARS|7407|nucleotide
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>VARS|7407|protein
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Evidence Statistic Top

Click the link of the category-specific score to view different category of evidences. The categories without any evidences are hidden by default.
Evidences Syndromic Gene GWAS Expression CNV Linkage Low Scale Association Other Studies Total
Score (No. of Studies) No 0 (0) 1 (1) 1 (2) 0 (0) 0 (0) 0 (0) 3 (1)
Syndromic Autism Gene Top
Low Scale Association Studies (by Ethnic Group) Top
Genome-Wide Association Studies(By Ethnic Group) Top
Other Low Scale Gene Studies Top
Large Scale Expression Studies Top
Microarray Studies: 1
Reference Population Tissue #Subjects
(% Women)
ADI-R ADOS Endo- pheno Diagnosis Normal Controls
(% Women)
Fold Change Up/ Down P/Q value
Gregg, 2008_2 mixed lymphoblastoid cell lines 17
(11.76%)
autism with early onset autism 12
(25.00%)
1.615 Up 0.0341
  • Platform: U133 Plus 2.0 GeneChip (Affymetrix,Santa Clara, CA, USA)
  • ProbeSet: 201797_s_at
  • RefSeq_ID/ EST: NM_006295
  • GEO_ID: GSE6575
  • Statistic Method: a stringent 1.5-fold unpaired t test with Benjamini
Proteomics Studies:0
Reference Population Tissue Platform #Subjects
(% Women)
ADI-R ADOS Diagnosis Normal Controls(% Women)
No Evidence.
CNV Studies Top
CNV Name Chr Band Gain/Loss Number of CNVs Evidence Type Reference
Case Control
AutCNV0000488 6 6p21.32-21.33 Gain 2 - Overlapping/Recurrent CNVs; Gregory, 2009
AutCNV0000489 6 6p21.32-21.33 Gain 1 - Overlapping/Recurrent CNVs; Gregory, 2009
AutCNV0000490 6 6p21.32-21.33 Gain 1 - Overlapping/Recurrent CNVs; Gregory, 2009
AutCNV0000699 6 6p21 Gain - - CNVs Only Present In Patients; CNVs Not Present In Control; Berkel, 2010
Linkage Studies Top

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  (e.g. NLGN4X)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 616
  • Genes: 3,075
  • SNPs/VNTRs: 3,386
  • CNVs: 4,617
  • Linkage Regions: 158
  • Last Update: 05/25/2012
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