AutismKB

Evidence Detail for LRRN3


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Basic Information Top
Gene Symbol:LRRN3 ( FIGLER5,FLJ11129,NLRR-3,NLRR3 )
Gene Full Name: leucine rich repeat neuronal 3
Band: 7q31.1
Quick LinksEntrez ID:54674; OMIM: ; Uniprot ID:LRRN3_HUMAN; ENSEMBL ID: ENSG00000173114
Sequences Top
>LRRN3|54674|nucleotide
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>LRRN3|54674|protein
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Evidence Statistic Top

Click the link of the category-specific score to view different category of evidences. The categories without any evidences are hidden by default.
Evidences Syndromic Gene GWAS Expression CNV Linkage Low Scale Association Other Studies Total
Score (No. of Studies) No 0 (0) 0 (0) 1 (3) 1 (1) 0 (1) 1 (1) 10 (3)
Syndromic Autism Gene Top
Low Scale Association Studies (by Ethnic Group) Top
Family Based Association Studies: 1
Case Control Based Association Studies: 0
Reference Population #SNPs/ #VNTRs ASD Cases Normal Controls Result
#Subjects
(% Women)
ADI-R ADOS Diagnosis Age
(range)
IQ #Subjects
(% Women)
Age
(range)
No Evidence.
Genome-Wide Association Studies(By Ethnic Group) Top
Other Low Scale Gene Studies Top
Reference Orangnism Tissue ADI-R ADOS Diagnosis Evidence Level Result
Sousa, 2010_1 human bloodASD genetics: association study
  • Subjects: 661
  • Normal Controls: -
  • Methods: direct sequencing
  • Evidence Details: Significant results were found for LRRN3 and LRRTM3 (P < 0.005), using both single locus and haplotype approaches
Large Scale Expression Studies Top
CNV Studies Top
CNV Name Chr Band Gain/Loss Number of CNVs Evidence Type Reference
Case Control
AutCNV0000142 7 7q31.1-31.31 loss 1 - Denovo CNVs; Marshall, 2008
AutCNV0000667 7 7q31.1 loss 1 - Overlapping/Recurrent CNVs; Pagnamenta, 2010
AutCNV0000668 7 7q31.1 loss 1 - Overlapping/Recurrent CNVs; Pagnamenta, 2010
AutCNV0004266 7 7q31.1-q31.31 loss 1 - Overlapping/Recurrent CNVs; Sanders, 2011
Linkage Studies Top
Linkage Name Band Chr Marker LOD NPL P_Value Reference
AutLD0000058 7q31.1 7 D7S523 1.02 - - Liu, 2001

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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 616
  • Genes: 3,075
  • SNPs/VNTRs: 3,386
  • CNVs: 4,617
  • Linkage Regions: 158
  • Last Update: 05/25/2012
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