Evidence Detail for IL6

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Basic Information Top
Gene Symbol:IL6 ( BSF2,HGF,HSF,IFNB2,IL-6 )
Gene Full Name: interleukin 6 (interferon, beta 2)
Band: 7p21
Quick LinksEntrez ID:3569; OMIM: 147620; Uniprot ID:IL6_HUMAN; ENSEMBL ID: ENSG00000136244
Sequences Top
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Evidence Statistic Top

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Evidences Syndromic Gene GWAS Expression CNV Linkage Low Scale Association Other Studies Total
Score (No. of Studies) No 0 (0) 0 (0) 0 (0) 0 (0) 0 (0) 1 (1) 7 (1)
Syndromic Autism Gene Top
Low Scale Association Studies (by Ethnic Group) Top
Genome-Wide Association Studies(By Ethnic Group) Top
Other Low Scale Gene Studies Top
Reference Orangnism Tissue ADI-R ADOS Diagnosis Evidence Level Result
Wei, 2011_1 mouse mouse cerebellar granule cells--- expression level
  • Subjects: -
  • Normal Controls: -
  • Methods: In vitro adnoviral gene delivery approach, cell adhesion and migration assays, Dil labeling, immunofluorscence
  • Evidence Details: In this study, we found that IL-6 was significant increased in the cerebellum of autistic subjects. We demonstrated that IL-6 over-expression in granule cells caused impairments in granule cell adhesion and migration but had little effect on the formation o fdendritic spines or granule cell apoptosis. However, IL-6 over-expression stimulated the formation of granule cell excitatory synapses, without affecting inhibitory synapses
Large Scale Expression Studies Top
CNV Studies Top
Linkage Studies Top

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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 616
  • Genes: 3,075
  • SNPs/VNTRs: 3,386
  • CNVs: 4,617
  • Linkage Regions: 158
  • Last Update: 05/25/2012
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