Evidence Detail for NTF4

View Evidences View Annotations
Basic Information Top
Gene Symbol:NTF4 ( GLC10,GLC1O,NT-4/5,NT4,NT5,NTF5 )
Gene Full Name: neurotrophin 4
Band: 19q13.3
Quick LinksEntrez ID:4909; OMIM: 162662; Uniprot ID:NTF4_HUMAN; ENSEMBL ID: ENSG00000167744
Sequences Top
Show »

Show »

Evidence Statistic Top

Click the link of the category-specific score to view different category of evidences. The categories without any evidences are hidden by default.
Evidences Syndromic Gene GWAS Expression CNV Linkage Low Scale Association Other Studies Total
Score (No. of Studies) No 0 (0) 0 (0) 1 (1) 1 (1) 1 (1) 2 (2) 20 (5)
Syndromic Autism Gene Top
Low Scale Association Studies (by Ethnic Group) Top
Family Based Association Studies: 0
Case Control Based Association Studies: 1
Reference Population #SNPs/ #VNTRs ASD Cases Normal Controls Result
(% Women)
ADI-R ADOS Diagnosis Age
IQ #Subjects
(% Women)
Toma, 2012_1 Spanish 1 (detail) 326
ASD 17
- 350
Genome-Wide Association Studies(By Ethnic Group) Top
Other Low Scale Gene Studies Top
Reference Orangnism Tissue ADI-R ADOS Diagnosis Evidence Level Result
Nelson, 2001_1 human neonatal blood--ASD protein expression
  • Subjects: 69
  • Normal Controls: 54
  • Methods: recycling immunoaffinity chromatography
  • Evidence Details: We used recycling immunoaffinity chromatography to measure the neuropeptides substance P (SP), vasoactive intestinal peptide (VIP), pituitary adenylate cyclase-activating polypeptide (PACAP), calcitonin gene-related peptide (CGRP), and the neurotrophins nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), neurotrophin 3 (NT3), and neurotrophin 4/5 (NT4/5). Neonatal concentrations of VIP, CGRP, BDNF, and NT4/5 were higher (ANOVA, all p values < 0.0001 by Scheffe test for pairwise differences) in children in the autistic spectrum and in those with mental retardation without autism than in control children.
Nelson, 2006_1 human neonatal blood--AD protein expression
  • Subjects: -
  • Normal Controls: -
  • Methods: double-antibody immunoaffinity assay (Luminex) and ELISA technology
  • Evidence Details: Concentrations of NT-4/5 and CGRP were correlated in infants with autism but not in Down syndrome or controls.
Large Scale Expression Studies Top
CNV Studies Top
CNV Name Chr Band Gain/Loss Number of CNVs Evidence Type Reference
Case Control
AutCNV0000648 19 19q13.33 Loss 1 - Overlapping/Recurrent CNVs; Gregory, 2009
Linkage Studies Top
Linkage Name Band Chr Marker LOD NPL P_Value Reference
AutLD0000119 19q13.33-13.41 19 - - 1.64 - Spence, 2006

Contact Us if you are an author of a study regarding this gene and do not find your study in this table or find errors in the representation of your study details.

Quick Search:

  (e.g. NLGN4X)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 616
  • Genes: 3,075
  • SNPs/VNTRs: 3,386
  • CNVs: 4,617
  • Linkage Regions: 158
  • Last Update: 05/25/2012
  • Click to Download Data

Registered with NIF