Evidence Detail for EN2


Gene Symbol: | EN2 ( - ) |
---|---|
Gene Full Name: | engrailed homeobox 2 |
Band: | 7q36 |
Quick Links | Entrez ID:2020; OMIM: 131310; Uniprot ID:HME2_HUMAN; ENSEMBL ID: ENSG00000164778 |




Click the link of the category-specific score to view different category of evidences. The categories without any evidences are hidden by default.
Evidences | Syndromic Gene | GWAS | Expression | CNV | Linkage | Low Scale Association | Other Studies | Total |
---|---|---|---|---|---|---|---|---|
Score (No. of Studies) | No | 0 (1) | 0 (0) | 0 (0) | 0 (0) | 3 (12) | 3 (4) | 30 (20) |




Family Based Association Studies: 9
Reference | Population | #SNPs/ #VNTRs | #Families | Affecteds | Result | |||||
---|---|---|---|---|---|---|---|---|---|---|
#Subjects (% Women) |
ADI-R | ADOS | Diagnosis | Age (range) |
IQ (range) |
|||||
CAUCASIAN | ||||||||||
Zhong, 2003_1 | AGRE | 1 (detail) | 196 | 437 (-) | ![]() | ![]() | ASD | - - |
- - | |
Gharani, 2004_1 | AGRE | 4 (detail) | 167 | 167 (-) | ![]() | ![]() | ASD | - - |
- - | |
Benayed, 2005_3 | NIMH | 2 (detail) | 129 | - (-) | ![]() | ![]() | ASD | - - |
- - | |
Benayed, 2005_2 | AGRE | 2 (detail) | 222 | - (-) | ![]() | ![]() | ASD | - - |
- - | |
Benayed, 2005_1 | AGRE | 16 (detail) | 167 | - (-) | ![]() | ![]() | ASD | - - |
- - | |
Carayol, 2010_1 | USA | 1 (detail) | 222 | 527 (22.22%) | ![]() | ![]() | autism | - - |
- - | |
Sen, 2010_1 | India | 4 (detail) | 128 | 128 (17.19%) | ![]() | ![]() | ASD | 5.98±3.1 - |
- - | |
ASIAN | ||||||||||
Wang, 2008_1 | China | 8 (detail) | 210 | 210 (6.67%) | ![]() | ![]() | AD | 6.5 (2-17) |
- - | |
MIXED/OTHERS | ||||||||||
Brune, 2008_1 | USA | 1 (detail) | 643 | - (-) | ![]() | ![]() | ASD,AD | - - |
- - |
Case Control Based Association Studies: 3
Reference | Population | #SNPs/ #VNTRs | ASD Cases | Normal Controls | Result | ||||||
---|---|---|---|---|---|---|---|---|---|---|---|
#Subjects (% Women) |
ADI-R | ADOS | Diagnosis | Age (range) |
IQ | #Subjects (% Women) |
Age (range) |
||||
CAUCASIAN | |||||||||||
Petit, 1995_1 | USA | 2 (detail) | 100 (34.00%) | ![]() | ![]() | AD | 7.33 (2-16) |
- | 100 (46.00%) |
8.17 - | |
ASIAN | |||||||||||
Yang, 2008_2 | China | 2 (detail) | 184 (-) | ![]() | ![]() | ASD | 7.06±4.35 - |
- | 225 (-) |
18.82±5.36 - | |
Yang, 2008_1 | China | 2 (detail) | 184 (-) | ![]() | ![]() | ASD | 7.06±4.35 - |
- | 409 (-) |
45.14±14 - |


Family Based Association Studies: 1
Reference | Stage | #SNPs/ #VNTRs | #Families | Affecteds | Result | ||||||
---|---|---|---|---|---|---|---|---|---|---|---|
#Subjects (% Women) |
ADI-R | ADOS | Diagnosis | Age (range) |
IQ (range) |
||||||
CAUCASIAN | |||||||||||
Hussman, 2011_1 | Discovery | 1 (detail) | 597 | - (-) | ![]() | ![]() | ASD | - - |
- - |
Case Control Based Association Studies: 0
Reference | Stage | #SNPs/ #VNTRs | ASD Cases | Normal Controls | Result | |||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
#Subjects (% Women) |
ADI-R | ADOS | Diagnosis | Age (range) |
IQ | #Subjects (% Women) |
Age (range) |
|||||
No Evidence. |


Reference | Orangnism | Tissue | ADI-R | ADOS | Diagnosis | Evidence Level | Result | |||
---|---|---|---|---|---|---|---|---|---|---|
Benayed, 2005_1 | rat | E14.5 cell | - | - | - | RNA expression | ||||
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Benayed, 2009_1 | human | HEK293T cells | - | - | - | RNA expression | ||||
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Benayed, 2009_1 | human | HEK293T cells | - | - | - | RNA regulation: splicing | ||||
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Benayed, 2009_2 | mouse | P6 mouse granule neurons cultured for 24 hours | - | - | - | RNA regulation | ||||
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Carayol, 2011_1 | human | blood | ![]() | ![]() | ASD | genetic score model | ||||
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Choi, 2011_1 | mouse | neurons | - | - | - | Animal model | ||||
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