AutismKB


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Enriched Enriched GO by DAVID

The GO-enriched analysis was done by DAVID using 171 confident genes, including the ranked non-syndromic genes (Score>=16) and level 3/4 syndromic genes.(Cutoff of enriched GO: P <= 1.00e-3)
Biological ProcessCellular ComponentMolecular Function
Biological Process
TermCount%P ValueFold EnrichmentFDRGenes
GO:0007610~behavior 38 22.22 4.62E-21 6.98 7.96E-18
54413 | 3265 | 4128 | 7249 | 6323 | 5021 | 2334 | 3845 | 5048 | 1312 | 2898 | 3778 | 2558 | 627 | 552 | 4233 | 1621 | 1137 | 5728 | 596 | 4763 | 11141 | 2925 | 5604 | 775 | 5649 | 57502 | 6899 | 93986 | 8195 | 186 | 1141 | 1814 | 1815 | 55079 | 55636 | 2182 | 5594 |
GO:0019226~transmission of nerve impulse 31 18.13 3.97E-18 7.63 6.84E-15
2562 | 54413 | 4128 | 1760 | 6323 | 5021 | 5048 | 1312 | 2898 | 3751 | 3778 | 2558 | 4908 | 1621 | 1756 | 9378 | 1137 | 4763 | 2571 | 777 | 775 | 5053 | 7915 | 7248 | 6532 | 1141 | 26047 | 1814 | 1815 | 2567 | 5594 |
GO:0007611~learning or memory 19 11.11 4.33E-16 14.75 7.66E-13
3265 | 5728 | 54413 | 4763 | 11141 | 2925 | 775 | 5021 | 2334 | 5048 | 3845 | 1312 | 93986 | 627 | 2558 | 1141 | 1814 | 1621 | 2182 |
GO:0007268~synaptic transmission 27 15.79 6.64E-16 7.81 1.14E-12
2562 | 54413 | 4128 | 1760 | 5021 | 5048 | 1312 | 2898 | 3751 | 3778 | 2558 | 4908 | 1621 | 1756 | 9378 | 1137 | 2571 | 777 | 775 | 5053 | 7915 | 6532 | 1141 | 1814 | 1815 | 2567 | 5594 |
GO:0030030~cell projection organization 29 16.96 1.38E-15 6.79 2.30E-12
5781 | 7249 | 5048 | 3897 | 170302 | 3198 | 23191 | 4983 | 80184 | 2245 | 389549 | 627 | 4908 | 2290 | 10716 | 23322 | 1641 | 1756 | 9378 | 5728 | 596 | 5604 | 778 | 5649 | 7248 | 8195 | 9037 | 1141 | 55079 |
GO:0048858~cell projection morphogenesis 24 14.04 7.03E-15 8.44 1.20E-11
9378 | 1756 | 596 | 5781 | 5604 | 5048 | 778 | 5649 | 3897 | 170302 | 3198 | 8195 | 23191 | 9037 | 4983 | 389549 | 627 | 1141 | 4908 | 2290 | 23322 | 10716 | 55079 | 1641 |
GO:0048666~neuron development 27 15.79 1.37E-14 6.86 2.35E-11
6121 | 5781 | 5048 | 3897 | 3198 | 170302 | 23191 | 4983 | 80184 | 389549 | 627 | 4908 | 2290 | 10716 | 1641 | 1756 | 9378 | 5728 | 596 | 5604 | 778 | 5649 | 9037 | 2020 | 1141 | 26047 | 55079 |
GO:0032990~cell part morphogenesis 24 14.04 1.82E-14 8.08 3.14E-11
9378 | 1756 | 596 | 5781 | 5604 | 5048 | 778 | 5649 | 3897 | 170302 | 3198 | 8195 | 23191 | 9037 | 4983 | 389549 | 627 | 1141 | 4908 | 2290 | 23322 | 10716 | 55079 | 1641 |
GO:0050877~neurological system process 48 28.07 3.04E-14 3.42 5.24E-11
2562 | 3265 | 6121 | 54413 | 4128 | 1760 | 2334 | 5021 | 6323 | 3845 | 5048 | 1312 | 2898 | 3751 | 3778 | 2558 | 627 | 4908 | 1621 | 9378 | 1756 | 1137 | 5728 | 4763 | 2571 | 11141 | 777 | 2925 | 775 | 778 | 501 | 5053 | 7915 | 6899 | 93986 | 8195 | 7248 | 186 | 6532 | 1141 | 26047 | 1814 | 4693 | 1815 | 2567 | 55636 | 2182 | 5594 |
GO:0048812~neuron projection morphogenesis 22 12.87 4.33E-14 8.90 7.46E-11
9378 | 1756 | 596 | 5781 | 5604 | 5048 | 778 | 5649 | 3897 | 170302 | 3198 | 23191 | 9037 | 4983 | 389549 | 627 | 1141 | 4908 | 2290 | 10716 | 55079 | 1641 |
GO:0030900~forebrain development 19 11.11 1.32E-13 10.77 2.27E-10
4763 | 5021 | 5048 | 5649 | 170302 | 93986 | 8195 | 7248 | 546 | 5013 | 6532 | 389549 | 1141 | 5307 | 7531 | 2290 | 23322 | 552 | 55079 |
GO:0031175~neuron projection development 23 13.45 1.76E-13 7.74 3.04E-10
9378 | 1756 | 5728 | 596 | 5781 | 5604 | 5048 | 778 | 5649 | 3897 | 170302 | 3198 | 23191 | 9037 | 4983 | 389549 | 627 | 1141 | 4908 | 2290 | 10716 | 55079 | 1641 |
GO:0035176~social behavior 10 5.85 2.39E-13 45.35 4.12E-10
54413 | 6899 | 8195 | 2925 | 5021 | 1141 | 1814 | 1815 | 552 | 57502 |
GO:0007409~axonogenesis 20 11.70 7.83E-13 8.93 1.35E-9
9378 | 596 | 5781 | 5048 | 778 | 5649 | 3897 | 170302 | 3198 | 23191 | 9037 | 4983 | 389549 | 627 | 1141 | 4908 | 2290 | 10716 | 55079 | 1641 |
GO:0030182~neuron differentiation 28 16.37 7.94E-13 5.51 1.37E-9
6121 | 5781 | 5048 | 3897 | 3198 | 3778 | 170302 | 23191 | 4983 | 80184 | 389549 | 627 | 4908 | 2290 | 10716 | 1641 | 1756 | 9378 | 5728 | 596 | 5604 | 778 | 5649 | 9037 | 2020 | 1141 | 26047 | 55079 |
GO:0007267~cell-cell signaling 32 18.71 1.39E-12 4.60 2.40E-9
2562 | 54413 | 4128 | 1760 | 5021 | 5048 | 1312 | 2898 | 3481 | 3751 | 3778 | 627 | 2558 | 4908 | 1621 | 1756 | 9378 | 1137 | 2571 | 777 | 775 | 5053 | 7915 | 9037 | 6532 | 1141 | 11069 | 1814 | 4693 | 1815 | 2567 | 5594 |
GO:0048667~cell morphogenesis involved in neuron differentiation 20 11.70 3.27E-12 8.25 5.63E-9
9378 | 596 | 5781 | 5048 | 778 | 5649 | 3897 | 170302 | 3198 | 23191 | 9037 | 4983 | 389549 | 627 | 1141 | 4908 | 2290 | 10716 | 55079 | 1641 |
GO:0000902~cell morphogenesis 24 14.04 1.83E-11 5.81 3.15E-8
9378 | 1756 | 596 | 5781 | 5604 | 5048 | 778 | 5649 | 3897 | 170302 | 3198 | 8195 | 23191 | 9037 | 4983 | 389549 | 627 | 1141 | 4908 | 2290 | 23322 | 10716 | 55079 | 1641 |
GO:0032989~cellular component morphogenesis 25 14.62 2.58E-11 5.43 4.44E-8
5781 | 5048 | 3897 | 3198 | 170302 | 23191 | 4983 | 389549 | 627 | 7273 | 4908 | 2290 | 10716 | 23322 | 1641 | 9378 | 1756 | 596 | 5604 | 778 | 5649 | 8195 | 9037 | 1141 | 55079 |
GO:0000904~cell morphogenesis involved in differentiation 20 11.70 4.98E-11 7.06 8.58E-8
9378 | 596 | 5781 | 5048 | 778 | 5649 | 3897 | 170302 | 3198 | 23191 | 9037 | 4983 | 389549 | 627 | 1141 | 4908 | 2290 | 10716 | 55079 | 1641 |
GO:0051705~behavioral interaction between organisms 10 5.85 1.56E-10 24.62 2.69E-7
54413 | 6899 | 8195 | 2925 | 5021 | 1141 | 1814 | 1815 | 552 | 57502 |
GO:0007612~learning 11 6.43 1.43E-9 15.80 2.46E-6
3265 | 54413 | 93986 | 4763 | 775 | 2558 | 1141 | 3845 | 1814 | 1312 | 1621 |
GO:0044057~regulation of system process 20 11.70 2.74E-9 5.58 4.71E-6
3265 | 54413 | 5781 | 1760 | 5604 | 775 | 5021 | 3845 | 2898 | 3481 | 3778 | 186 | 627 | 1141 | 4909 | 1814 | 4908 | 1815 | 552 | 1621 |
GO:0021537~telencephalon development 11 6.43 3.23E-9 14.58 5.57E-6
170302 | 93986 | 4763 | 7248 | 8195 | 5021 | 5048 | 7531 | 552 | 23322 | 5649 |
GO:0007411~axon guidance 13 7.60 3.49E-9 10.47 6.01E-6
9378 | 3897 | 5649 | 3198 | 170302 | 9037 | 4983 | 627 | 389549 | 4908 | 2290 | 10716 | 55079 |
GO:0008542~visual learning 8 4.68 1.73E-8 25.53 2.99E-5
3265 | 54413 | 4763 | 775 | 1141 | 3845 | 1814 | 1621 |
GO:0048878~chemical homeostasis 24 14.04 2.16E-8 4.04 3.71E-5
1137 | 54413 | 596 | 4763 | 5781 | 1760 | 777 | 5579 | 775 | 5021 | 6323 | 778 | 2898 | 3481 | 3751 | 3778 | 7248 | 10479 | 1141 | 4908 | 1814 | 1815 | 552 | 1621 |
GO:0006928~cell motion 23 13.45 2.62E-8 4.17 4.52E-5
9378 | 1767 | 5728 | 5604 | 5048 | 5649 | 3897 | 170302 | 3198 | 6899 | 9037 | 4983 | 389549 | 627 | 4908 | 7531 | 2290 | 10716 | 23314 | 4233 | 1621 | 55079 | 1641 |
GO:0042391~regulation of membrane potential 13 7.60 4.54E-8 8.36 7.82E-5
1137 | 54413 | 596 | 4763 | 1760 | 6323 | 2898 | 3751 | 3778 | 7248 | 1141 | 4908 | 1815 |
GO:0007632~visual behavior 8 4.68 4.94E-8 22.24 8.51E-5
3265 | 54413 | 4763 | 775 | 1141 | 3845 | 1814 | 1621 |
GO:0030534~adult behavior 11 6.43 5.20E-8 11.02 8.96E-5
1137 | 3778 | 775 | 6323 | 5048 | 1141 | 1814 | 1815 | 4233 | 1621 | 55636 |
GO:0050801~ion homeostasis 20 11.70 2.43E-7 4.21 4.18E-4
1137 | 54413 | 596 | 4763 | 1760 | 5579 | 775 | 5021 | 6323 | 778 | 2898 | 3751 | 3778 | 7248 | 10479 | 1141 | 4908 | 1814 | 1815 | 552 |
GO:0033555~multicellular organismal response to stress 8 4.68 2.67E-7 17.67 4.60E-4
2898 | 596 | 627 | 2558 | 1815 | 1312 | 5649 | 1621 |
GO:0006873~cellular ion homeostasis 19 11.11 3.07E-7 4.38 5.28E-4
1137 | 54413 | 596 | 4763 | 1760 | 5579 | 775 | 5021 | 6323 | 778 | 2898 | 3751 | 3778 | 7248 | 1141 | 1814 | 4908 | 1815 | 552 |
GO:0055082~cellular chemical homeostasis 19 11.11 3.88E-7 4.31 6.68E-4
1137 | 54413 | 596 | 4763 | 1760 | 5579 | 775 | 5021 | 6323 | 778 | 2898 | 3751 | 3778 | 7248 | 1141 | 1814 | 4908 | 1815 | 552 |
Cellular Component
TermCount%P ValueFold EnrichmentFDRGenes
GO:0045202~synapse 25 14.62 3.05E-13 6.62 3.98e-10
2562 | 54413 | 2560 | 8573 | 3897 | 2898 | 3751 | 3778 | 23191 | 4983 | 2558 | 2557 | 1756 | 9378 | 1137 | 23705 | 2571 | 22941 | 775 | 2892 | 1141 | 2567 | 116444 | 9783 | 85358 |
GO:0042995~cell projection 31 18.13 2.76E-11 4.18 3.60e-8
2562 | 1767 | 7249 | 6323 | 5021 | 5048 | 3897 | 2898 | 3751 | 3778 | 23191 | 4983 | 80184 | 2245 | 23322 | 1621 | 4233 | 1137 | 23705 | 4763 | 2571 | 4035 | 775 | 5604 | 2892 | 5649 | 6326 | 7248 | 8195 | 1814 | 5594 |
GO:0043005~neuron projection 22 12.87 6.64E-11 6.05 8.68e-8
2562 | 1137 | 23705 | 4763 | 2571 | 5604 | 775 | 4035 | 6323 | 2892 | 7249 | 5048 | 5649 | 3897 | 6326 | 2898 | 3751 | 3778 | 7248 | 4983 | 1621 | 5594 |
GO:0044456~synapse part 18 10.53 8.40E-10 6.88 1.10e-6
9378 | 2562 | 1137 | 23705 | 2560 | 775 | 22941 | 2892 | 3897 | 2898 | 3751 | 3778 | 2558 | 1141 | 2557 | 2567 | 116444 | 85358 |
GO:0030424~axon 14 8.19 1.23E-8 8.28 1.61e-5
2562 | 23705 | 2571 | 4763 | 5604 | 6323 | 2892 | 3897 | 6326 | 2898 | 3778 | 4983 | 1621 | 5594 |
GO:0045211~postsynaptic membrane 13 7.60 1.80E-8 9.05 2.36e-5
2562 | 1137 | 2560 | 22941 | 2892 | 2898 | 3778 | 2558 | 1141 | 2557 | 2567 | 116444 | 85358 |
GO:0005626~insoluble fraction 29 16.96 4.08E-8 3.25 5.33e-5
3265 | 6323 | 7249 | 8573 | 5048 | 3845 | 1312 | 3897 | 2898 | 3751 | 23191 | 1621 | 4233 | 55624 | 1756 | 1137 | 23705 | 596 | 4035 | 775 | 2892 | 6326 | 7248 | 10479 | 6532 | 11069 | 1814 | 2182 | 5594 |
GO:0000267~cell fraction 33 19.30 6.37E-8 2.86 8.32e-5
3265 | 5781 | 6323 | 7249 | 8573 | 5048 | 3845 | 2332 | 1312 | 3897 | 2898 | 3751 | 23191 | 55624 | 1621 | 4233 | 1756 | 1137 | 23705 | 596 | 5604 | 4035 | 775 | 2892 | 6326 | 7915 | 7248 | 10479 | 6532 | 11069 | 1814 | 2182 | 5594 |
GO:0005624~membrane fraction 28 16.37 7.47E-8 3.25 9.76e-5
3265 | 6323 | 7249 | 8573 | 5048 | 3845 | 1312 | 3897 | 2898 | 3751 | 23191 | 1621 | 4233 | 55624 | 1756 | 1137 | 23705 | 596 | 4035 | 775 | 2892 | 6326 | 7248 | 10479 | 6532 | 11069 | 1814 | 2182 |
GO:0030425~dendrite 13 7.60 1.47E-7 7.50 1.92e-4
1137 | 23705 | 4763 | 4035 | 775 | 5604 | 2892 | 7249 | 5649 | 2898 | 3751 | 4983 | 5594 |
GO:0043025~cell soma 13 7.60 2.05E-7 7.27 2.68e-4
1137 | 777 | 4035 | 775 | 5604 | 6323 | 2892 | 7249 | 5048 | 2898 | 3751 | 116444 | 5594 |
GO:0034702~ion channel complex 14 8.19 2.50E-7 6.42 3.26e-4
2562 | 1137 | 2560 | 777 | 775 | 6323 | 778 | 6326 | 3751 | 3778 | 2558 | 1141 | 2557 | 2567 |
Molecular Function
TermCount%P ValueFold EnrichmentFDRGenes
GO:0005230~extracellular ligand-gated ion channel activity 10 5.85 1.18E-7 12.10 1.64e-4
2562 | 2898 | 1137 | 2560 | 2892 | 2558 | 1141 | 2557 | 2567 | 116444 |
GO:0022836~gated channel activity 17 9.94 4.83E-7 4.78 6.74e-4
2562 | 1137 | 2560 | 777 | 775 | 2892 | 6323 | 778 | 6326 | 2898 | 3751 | 3778 | 2558 | 1141 | 2557 | 2567 | 116444 |

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  (e.g. NLGN4X)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 616
  • Genes: 3,075
  • SNPs/VNTRs: 3,386
  • CNVs: 4,617
  • Linkage Regions: 158
  • Last Update: 05/25/2012
  • Click to Download Data

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