AutismKB

Annotation Detail for NR2F1


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Basic Information Top
Gene Symbol:NR2F1 ( COUP-TFI,EAR-3,EAR3,ERBAL3,NR2F2,SVP44,TCFCOUP1,TFCOUP1 )
Gene Full Name: nuclear receptor subfamily 2, group F, member 1
Band: 5q14
Quick LinksEntrez ID:7025; OMIM: 132890; Uniprot ID:COT1_HUMAN; ENSEMBL ID: ENSG00000175745
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005634IDA-nucleus10644740
GO:0005654TAS-nucleoplasm-
GO ID Evidence Qualifier GO_term References
GO:0003700IDA-sequence-specific DNA binding transcription factor activity10644740
GO:0003706TAS-ligand-regulated transcription factor activity8530078
GO:0003707IEA-steroid hormone receptor activity-
GO:0003713TAS-transcription coactivator activity2739739
GO:0004879TAS-ligand-dependent nuclear receptor activity8530078
GO:0008270IEA-zinc ion binding-
GO:0043565IDA-sequence-specific DNA binding10644740
GO:0046872IEA-metal ion binding-
GO ID Evidence Qualifier GO_term References
GO:0000122IDA-negative regulation of transcription from RNA polymerase II promoter10644740
GO:0001764IEA-neuron migration-
GO:0006351IDA-transcription, DNA-dependent10644740
GO:0006351TAS-transcription, DNA-dependent2739739
GO:0006355IEA-regulation of transcription, DNA-dependent-
GO:0007165TAS-signal transduction2739739
GO:0010467TAS-gene expression-
GO:0030900IEA-forebrain development-
GO:0034339TAS-regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
NR2F1AHR10669910620335 Reconstituted Complex
NR2F1AHR11288310620335 Reconstituted Complex
NR2F1ESR110840312093745 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
NR2F1ESR111288312093745 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
NR2F1GTF2B1128831517211 Reconstituted Complex
NR2F1GTF2B1092141517211 Reconstituted Complex
NR2F1ISL111288311043578 Reconstituted Complex
NR2F1ISL110987711043578 Reconstituted Complex
NR2F1SP11125509388268 15849318 Reconstituted Complex
NR2F1SP11128839388268 15849318 Reconstituted Complex
COPS2NR2F111288310207062 Reconstituted Complex
COPS2NR2F111472910207062 Reconstituted Complex
GRIP1NR2F111699510652338 Two-hybrid
GRIP1NR2F111288310652338 Two-hybrid
NCOA3NR2F111288310652338 Two-hybrid
NCOA3NR2F111384110652338 Two-hybrid
BCL11BNR2F112234310744719 15849318 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
BCL11BNR2F111288310744719 15849318 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
BCL11ANR2F111973710744719 Reconstituted Complex; Two-hybrid
BCL11ANR2F111288310744719 Reconstituted Complex; Two-hybrid
PHB2NR2F111288315140878 Reconstituted Complex
PHB2NR2F111645915140878 Reconstituted Complex
CBX5NR2F111703015849318 Reconstituted Complex
CBX5NR2F111288315849318 Reconstituted Complex
No data
No data
Genomic Variants Top
Variant ID Location Publication Method/platform Gain Lose Total Frequency Sample Size Genes
Variation_111261 chr5:92922102-92995424 20364138 Custom Agilent 24M oligonucleotide CGH array 2 0 2- 30 Asian Individuals (10 Koreans (KOR), 10 HapMap Chinese (CHB) and 10 HapMap Japanese (JPT) individuals) FLJ42709, MIR2277, NR2F1, FAM172A
Variation_69162 chr5:92945550-92946728 19812545 NimbleGen custom 42M oligo array CGH 0 1 1 NA 39 HapMap Individuals + NA15510 NR2F1
No data
No data
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AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:1352451
  • Data Attributes: MGI curated and HomoloGene calculated
MGI Allele ID Allele Symbol Allele Source Allele Type / Mutant Cell line ID
MGI:2385930Nr2f1[tm1Mjts]Allele from Mouse Targeted (knock-out)
  • nervous system phenotype
  • hearing/vestibular/ear phenotype
  • behavior/neurological phenotype
MGI:3521756Nr2f1[tm1Mist]Allele from Mouse Targeted (knock-out)
  • nervous system phenotype
MGI:4439069Nr2f1[tm2.1Mjts]Allele from Mouse Targeted (Floxed/Frt)
  • pigmentation phenotype
  • nervous system phenotype
  • vision/eye phenotype
MGI:4834594Nr2f1[tm2Mist]Allele from Mouse Targeted (Floxed/Frt)
  • no phenotypic analysis