AutismKB

Annotation Detail for TAP1


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Basic Information Top
Gene Symbol:TAP1 ( ABC17,ABCB2,APT1,D6S114E,FLJ26666,FLJ41500,PSF1,RING4,TAP1*0102N,TAP1N )
Gene Full Name: transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
Band: 6p21.3
Quick LinksEntrez ID:6890; OMIM: 170260; Uniprot ID:TAP1_HUMAN; ENSEMBL ID: ENSG00000168394
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005739IEA-mitochondrion-
GO:0005743ISSNOTmitochondrial inner membrane-
GO:0005783IEA-endoplasmic reticulum-
GO:0005789IEA-endoplasmic reticulum membrane-
GO:0005792IEA-microsome-
GO:0005829NAS-cytosol11133832
GO:0005886ISS-plasma membrane-
GO:0016021IDA-integral to membrane8955196
GO:0030176IDA-integral to endoplasmic reticulum membrane11133832
GO:0042825IDA-TAP complex11133832
GO:0042825ISS-TAP complex-
GO ID Evidence Qualifier GO_term References
GO:0000166IEA-nucleotide binding-
GO:0005215IEA-transporter activity-
GO:0005515IPI-protein binding12213826
GO:0005524IDA-ATP binding11133832
GO:0015197IGIcontributes_topeptide transporter activity7673167
GO:0015197IMP-peptide transporter activity17418234
GO:0015421ISS-oligopeptide-transporting ATPase activity-
GO:0016887IEA-ATPase activity-
GO:0042288ISS-MHC class I protein binding-
GO:0042605ISS-peptide antigen binding-
GO:0042605NAS-peptide antigen binding11133832
GO:0042626IEA-ATPase activity, coupled to transmembrane movement of substances-
GO:0042803ISS-protein homodimerization activity-
GO:0043531IDA-ADP binding11532960
GO:0046978ISS-TAP1 binding-
GO:0046979IPI-TAP2 binding11133832
GO:0046979ISS-TAP2 binding-
GO:0046980ISS-tapasin binding-
GO:0046982IEA-protein heterodimerization activity-
GO ID Evidence Qualifier GO_term References
GO:0001916ISS-positive regulation of T cell mediated cytotoxicity-
GO:0006952IEA-defense response-
GO:0015031IEA-protein transport-
GO:0015833IGI-peptide transport7673167
GO:0015833IMP-peptide transport11133832
GO:0015833ISS-peptide transport-
GO:0019060IMP-intracellular transport of viral proteins in host cell7538543
GO:0019885IMP-antigen processing and presentation of endogenous peptide antigen via MHC class I11133832
GO:0042270IEA-protection from natural killer cell mediated cytotoxicity-
GO:0044419IEA-interspecies interaction between organisms-
GO:0046967IMP-cytosol to ER transport7538543
GO:0055085ISS-transmembrane transport-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
TAP1COPB111275311884415 Affinity Capture-Western
TAP1COPB110771011884415 Affinity Capture-Western
TAP1PDIA31091809545232 Affinity Capture-MS
TAP1PDIA31127539545232 Affinity Capture-MS
TAP1HLA-A11275311884415 Affinity Capture-Western
TAP1HLA-A10935011884415 Affinity Capture-Western
TAP1HLA-G1093809103419 Affinity Capture-Western
TAP1HLA-G1127539103419 Affinity Capture-Western
TAP1MDFI11275316189514 Two-hybrid
TAP1MDFI11035316189514 Two-hybrid
TAP2TAP111275311381133 Reconstituted Complex
TAP2TAP111275411381133 Reconstituted Complex
COPGTAP111275311884415 Affinity Capture-Western
COPGTAP111649611884415 Affinity Capture-Western
TAPBPTAP111275311884415 12213826 Affinity Capture-Western; Reconstituted Complex
TAPBPTAP111275511884415 12213826 Affinity Capture-Western; Reconstituted Complex
KRTAP4-12TAP111275316189514 Two-hybrid
KRTAP4-12TAP112375616189514 Two-hybrid
No data
No data
Genomic Variants Top
AlzGene, PDGene and SZGene Top
Gene Symbol Poly Names Gene overview in AlzGene
TAP1rs1800453, rs4148880 Gene overview in AlzGene
No data
No data
Animal Model Top
  • MGI ID: MGI:98483
  • Data Attributes: MGI curated and HomoloGene calculated
MGI Allele ID Allele Symbol Allele Source Allele Type / Mutant Cell line ID
MGI:1857253Tap1[tm1Arp]Allele from Mouse Targeted (knock-out)
  • immune system phenotype
  • hematopoietic system phenotype
MGI:1858161Tap1[tm1Hpl]Allele from Mouse Targeted (knock-out)
  • tumorigenesis
  • immune system phenotype
MGI:4435485Tap1[tm1e(EUCOMM)Hmgu]Mutant from cell lines79869
-
MGI:4461619Tap1[tm2e(EUCOMM)Hmgu]Mutant from cell lines46020
-