AutismKB

Annotation Detail for NLGN4X


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Basic Information Top
Gene Symbol:NLGN4X ( ASPGX2,AUTSX2,HLNX,HNLX,KIAA1260,MGC22376,NLGN,NLGN4 )
Gene Full Name: neuroligin 4, X-linked
Band: Xp22.33
Quick LinksEntrez ID:57502; OMIM: 300427; Uniprot ID:NLGNX_HUMAN; ENSEMBL ID: ENSG00000146938
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005886IDA-plasma membrane19726642
GO:0005887IDA-integral to plasma membrane11368788
GO:0009986IDA-cell surface15150161
GO:0016021NAS-integral to membrane16377159
GO:0030425IDA-dendrite19726642
GO:0045202ISS-synapse18227507
GO ID Evidence Qualifier GO_term References
GO:0004091ISS-carboxylesterase activity-
GO:0005515IPI-protein binding11368788
GO:0031404IDA-chloride ion binding18093521
GO:0042043IDA-neurexin binding19726642
GO:0042043IPI-neurexin binding18093521
GO:0042803IDA-protein homodimerization activity18093521
GO ID Evidence Qualifier GO_term References
GO:0002124ISS-territorial aggressive behavior18227507
GO:0003360ISS-brainstem development18227507
GO:0007155IEA-cell adhesion-
GO:0007416IDA-synapse assembly19726642
GO:0008049ISS-male courtship behavior18227507
GO:0021549ISS-cerebellum development18227507
GO:0035176IMP-social behavior12669065
GO:0045216NAS-cell-cell junction organization11368788
GO:0046622ISS-positive regulation of organ growth18227507
GO:0050804ISS-regulation of synaptic transmission-
GO:0050808IMP-synapse organization15150161
GO:0050808NAS-synapse organization11368788
GO:0060079IDA-regulation of excitatory postsynaptic membrane potential19726642
GO:0071625ISS-vocalization behavior18227507
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
NLGN4XDLG412156711368788 Affinity Capture-Western
NLGN4XDLG410808611368788 Affinity Capture-Western
No data
No data
Genomic Variants Top
Variant ID Location Publication Method/platform Gain Lose Total Frequency Sample Size Genes
Variation_39570 chrX:5882705-5896518 18421352 Sequencing 0 1 1- 1 control sample (JD_Watson) NLGN4X
Variation_83305 chrX:6148429-6149719 19900272 Custom Affymetrix oligonucleotide arrays 1 0 1- 90 Yoruban Individuals for Ibadan Nigeria NLGN4X
Variation_96438 chrX:6148429-6149719 19900272 Custom Affymetrix oligonucleotide arrays 0 1 1- 90 Yoruban Individuals for Ibadan Nigeria NLGN4X
Variation_83304 chrX:6148429-6152643 19900272 Custom Affymetrix oligonucleotide arrays 4 0 4- 90 Yoruban Individuals for Ibadan Nigeria NLGN4X
Variation_96437 chrX:6148429-6152643 19900272 Custom Affymetrix oligonucleotide arrays 0 18 18- 90 Yoruban Individuals for Ibadan Nigeria NLGN4X
Variation_96440 chrX:6151095-6152643 19900272 Custom Affymetrix oligonucleotide arrays 0 1 1- 90 Yoruban Individuals for Ibadan Nigeria NLGN4X
Variant ID Location Publication Method/platform Gain Lose Total Frequency Sample Size Genes
Variation_109984 chrX:5834938-5835500 20482838 Custom Agilent 24M aCGH 1 0 1- 1 control sample (J. Craig Venter) NLGN4X
Variation_96439 chrX:6150579-6151095 19900272 Custom Affymetrix oligonucleotide arrays 0 1 1- 90 Yoruban Individuals for Ibadan Nigeria NLGN4X
Variant ID Location Publication Method/platform Gain Lose Total Frequency Sample Size Genes
Variation_59877 chrX:6146833-6148382 19470904 Illumina DNA sequencing 0 0 0- 1 male Korean individual, SJK NLGN4X
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
No data

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