AutismKB

Annotation Detail for MAPK3


View Evidences View Annotations
Basic Information Top
Gene Symbol:MAPK3 ( ERK1,HS44KDAP,HUMKER1A,MGC20180,P44ERK1,P44MAPK,PRKM3 )
Gene Full Name: mitogen-activated protein kinase 3
Band: 16p11.2
Quick LinksEntrez ID:5595; OMIM: 601795; Uniprot ID:MK03_HUMAN; ENSEMBL ID: ENSG00000102882
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005634IEA-nucleus-
GO:0005654EXP-nucleoplasm11741541
GO:0005654TAS-nucleoplasm-
GO:0005737IEA-cytoplasm-
GO:0005829EXP-cytosol16580177
GO:0005829TAS-cytosol-
GO ID Evidence Qualifier GO_term References
GO:0000166IEA-nucleotide binding-
GO:0001784IEA-phosphotyrosine binding-
GO:0004674EXP-protein serine/threonine kinase activity16626623
GO:0004707EXP-MAP kinase activity11741541
GO:0004707NAS-MAP kinase activity7687743
GO:0005515IPI-protein binding19776015
GO:0005524NAS-ATP binding-
GO:0016301EXP-kinase activity7739560
GO:0016301TAS-kinase activity-
GO:0019902IPI-phosphatase binding19494114
GO ID Evidence Qualifier GO_term References
GO:0000165NAS-MAPKKK cascade-
GO:0000165TAS-MAPKKK cascade-
GO:0000186TAS-activation of MAPKK activity-
GO:0000187TAS-activation of MAPK activity-
GO:0002224TAS-toll-like receptor signaling pathway-
GO:0002755EXP-MyD88-dependent toll-like receptor signaling pathway15276183
GO:0002755TAS-MyD88-dependent toll-like receptor signaling pathway-
GO:0002756EXP-MyD88-independent toll-like receptor signaling pathway15276183
GO:0002756TAS-MyD88-independent toll-like receptor signaling pathway-
GO:0006360TAS-transcription from RNA polymerase I promoter-
GO:0006361TAS-transcription initiation from RNA polymerase I promoter-
GO:0006468IDA-protein phosphorylation7687743
GO:0006974IEA-response to DNA damage stimulus-
GO:0007049IEA-cell cycle-
GO:0007173TAS-epidermal growth factor receptor signaling pathway-
GO:0007264EXP-small GTPase mediated signal transduction10712923
GO:0007265EXP-Ras protein signal transduction11520933
GO:0007411TAS-axon guidance-
GO:0007596TAS-blood coagulation-
GO:0008063TAS-Toll signaling pathway-
GO:0008286TAS-insulin receptor signaling pathway-
GO:0009887IEA-organ morphogenesis-
GO:0016310EXP-phosphorylation7739560
GO:0019233IEA-sensory perception of pain-
GO:0030168TAS-platelet activation-
GO:0031663IEA-lipopolysaccharide-mediated signaling pathway-
GO:0032496IEA-response to lipopolysaccharide-
GO:0033129IMP-positive regulation of histone phosphorylation-
GO:0034130TAS-toll-like receptor 1 signaling pathway-
GO:0034134TAS-toll-like receptor 2 signaling pathway-
GO:0034138TAS-toll-like receptor 3 signaling pathway-
GO:0034142TAS-toll-like receptor 4 signaling pathway-
GO:0035066IMP-positive regulation of histone acetylation-
GO:0043330IEA-response to exogenous dsRNA-
GO:0044419IEA-interspecies interaction between organisms-
GO:0045087TAS-innate immune response-
GO:0045944IMP-positive regulation of transcription from RNA polymerase II promoter-
GO:0048011TAS-nerve growth factor receptor signaling pathway-
GO:0051090TAS-regulation of sequence-specific DNA binding transcription factor activity-
GO:0051216IEA-cartilage development-
GO:0051403TAS-stress-activated MAPK cascade-
GO:0070498IMP-interleukin-1-mediated signaling pathway-
GO:0071260IEP-cellular response to mechanical stimulus19593445
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
MAPK3ARRB211158112473660 Affinity Capture-Western
MAPK3ARRB210690212473660 Affinity Capture-Western
MAPK3ATP1A111158115069082 Biochemical Activity
MAPK3ATP1A110696615069082 Biochemical Activity
MAPK3AVPR211158112473660 Affinity Capture-Western
MAPK3AVPR210703512473660 Affinity Capture-Western
MAPK3BRAF11158110869359 Phenotypic Enhancement
MAPK3BRAF10714110869359 Phenotypic Enhancement
MAPK3C1QBP11158111866440 Biochemical Activity
MAPK3C1QBP10716911866440 Biochemical Activity
MAPK3CDC25C11158116582626 Affinity Capture-Western; Reconstituted Complex
MAPK3CDC25C10743016582626 Affinity Capture-Western; Reconstituted Complex
MAPK3MAPK1411158112697810 Affinity Capture-Western
MAPK3MAPK1410781912697810 Affinity Capture-Western
MAPK3DCC11158111986622 Two-hybrid
MAPK3DCC10799811986622 Two-hybrid
MAPK3DUSP110817611278799 Two-hybrid
MAPK3DUSP111158111278799 Two-hybrid
MAPK3DUSP310817810224087 Affinity Capture-Western; Biochemical Activity
MAPK3DUSP311158110224087 Affinity Capture-Western; Biochemical Activity
MAPK3DUSP410817911387337 Reconstituted Complex
MAPK3DUSP411158111387337 Reconstituted Complex
MAPK3DUSP51081807836374 Biochemical Activity
MAPK3DUSP51115817836374 Biochemical Activity
MAPK3DUSP61081819535927 Affinity Capture-Western; Reconstituted Complex
MAPK3DUSP61115819535927 Affinity Capture-Western; Reconstituted Complex
MAPK3ETV111158111551945 Biochemical Activity
MAPK3ETV110841611551945 Biochemical Activity
MAPK3GMFB1115818639570 Affinity Capture-Western
MAPK3GMFB1090268639570 Affinity Capture-Western
MAPK3GTF2I11158110648599 Affinity Capture-Western; Biochemical Activity
MAPK3GTF2I10922410648599 Affinity Capture-Western; Biochemical Activity
MAPK3INSR11158111409918 Affinity Capture-Western
MAPK3INSR10985411409918 Affinity Capture-Western
MAPK3JUN1099281922387 Biochemical Activity
MAPK3JUN1115811922387 Biochemical Activity
MAPK3LYN11024511131153 Affinity Capture-Western
MAPK3LYN11158111131153 Affinity Capture-Western
MAPK3CIITA11158118245089 Affinity Capture-Western
MAPK3CIITA11041618245089 Affinity Capture-Western
MAPK3MYC11158115210690 Reconstituted Complex
MAPK3MYC11069415210690 Reconstituted Complex
THMAPK31129121347949 Biochemical Activity
THMAPK31115811347949 Biochemical Activity
MAP2K1MAPK31115818226933 8626767 9006895 9733512 10748187 Affinity Capture-Western; Biochemical Activity; Co-localization; Reconstituted Complex; Two-hybrid
MAP2K1MAPK31115908226933 8626767 9006895 9733512 10748187 Affinity Capture-Western; Biochemical Activity; Co-localization; Reconstituted Complex; Two-hybrid
MAP2K2MAPK31115818226933 8626767 9006895 Biochemical Activity; Reconstituted Complex; Two-hybrid
MAP2K2MAPK31115918226933 8626767 9006895 Biochemical Activity; Reconstituted Complex; Two-hybrid
MAP2K3MAPK31115818226933 Reconstituted Complex
MAP2K3MAPK31115928226933 Reconstituted Complex
SPIBMAPK31115818632909 Biochemical Activity; Co-purification
SPIBMAPK31125678632909 Biochemical Activity; Co-purification
RPS6KA2MAPK31115818939914 12832467 Affinity Capture-Western
RPS6KA2MAPK31121108939914 12832467 Affinity Capture-Western
RPS6KA3MAPK31115818939914 Affinity Capture-Western
RPS6KA3MAPK31121118939914 Affinity Capture-Western
MKNK1MAPK31141389155018 Biochemical Activity
MKNK1MAPK31115819155018 Biochemical Activity
MAPKSP1MAPK31142019733512 Affinity Capture-Western
MAPKSP1MAPK31115819733512 Affinity Capture-Western
RPS6KA4MAPK31144689792677 Affinity Capture-Western
RPS6KA4MAPK31115819792677 Affinity Capture-Western
PTPRRMAPK31115819857190 Reconstituted Complex
PTPRRMAPK31117659857190 Reconstituted Complex
PTPN5MAPK31243129857190 Reconstituted Complex
PTPN5MAPK31115819857190 Reconstituted Complex
PTPN7MAPK311174310206983 10559944 10702794 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
PTPN7MAPK311158110206983 10559944 10702794 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
SREBF1MAPK311259810627507 Biochemical Activity
SREBF1MAPK311158110627507 Biochemical Activity
SREBF2MAPK311259910627507 Biochemical Activity
SREBF2MAPK311158110627507 Biochemical Activity
TP53MAPK311301010958792 Affinity Capture-Western
TP53MAPK311158110958792 Affinity Capture-Western
HDAC4MAPK311158111114188 Affinity Capture-Western; Biochemical Activity
HDAC4MAPK311510611114188 Affinity Capture-Western; Biochemical Activity
RAF1MAPK311183111409918 Affinity Capture-Western
RAF1MAPK311158111409918 Affinity Capture-Western
PEA15MAPK311423011702783 Two-hybrid
PEA15MAPK311158111702783 Two-hybrid
SNCAMAPK311250612121974 Affinity Capture-Western
SNCAMAPK311158112121974 Affinity Capture-Western
SNCGMAPK311158112121974 Affinity Capture-Western
SNCGMAPK311250712121974 Affinity Capture-Western
IER3MAPK311439012356731 Affinity Capture-Western
IER3MAPK311158112356731 Affinity Capture-Western
UBR5MAPK311950112594221 Affinity Capture-Western
UBR5MAPK311158112594221 Affinity Capture-Western
RPS6KA1MAPK311158112832467 Affinity Capture-Western
RPS6KA1MAPK311210912832467 Affinity Capture-Western
BAZ1BMAPK311449719776015 Biochemical Activity
BAZ1BMAPK311158119776015 Biochemical Activity
No data
No data
Genomic Variants Top
Variant ID Location Publication Method/platform Gain Lose Total Frequency Sample Size Genes
Variation_35383 chr16:29357274-30120928 18451855 Paired End Mapping 0 1 1- 1 control sample (NA18507, YRI) FAM57B, GDPD3, CDIPT, INO80E, DOC2A, ASPHD1, QPRT, CORO1A, SULT1A3, C16orf92, SLC7A5P1, TBX6, C16orf54, TMEM219, SPN, BOLA2, MAPK3, SLX1B, PRRT2, LOC100271831, KCTD13, SLX1A, ALDOA, LOC388242, LOC440354, MAZ, LOC613038, BOLA2B, SEZ6L2, YPEL3, TAOK2, LOC606724, PPP4C, MVP, C16orf53, HIRIP3, SULT1A4, LOC440356
Variation_4940 chr16:29970761-30091982 17160897 BAC Array CGH 0 5 5- 95 control samples YPEL3, ALDOA, GDPD3, PPP4C, TBX6, MAPK3, LOC100271831
Variation_4001 chr16:29981456-30290781 17122850 BAC Array CGH 13- 270 control samples (HapMap) BOLA2B, LOC613038, YPEL3, CORO1A, LOC606724, TBC1D10B, ALDOA, GDPD3, PPP4C, LOC388242, SULT1A3, CD2BP2, TBX6, LOC440354, LOC595101, BOLA2, SULT1A4, MAPK3, SLX1B, LOC100271831, LOC613037, SLX1A
No data
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:1346859
  • Data Attributes: MGI curated and HomoloGene calculated
MGI Allele ID Allele Symbol Allele Source Allele Type / Mutant Cell line ID
MGI:2183906Mapk3[tm1Gpg]Allele from Mouse Targeted (knock-out)
  • nervous system phenotype
  • liver/biliary system phenotype
  • homeostasis/metabolism phenotype
  • growth/size phenotype
  • cellular phenotype
  • cardiovascular system phenotype
  • behavior/neurological phenotype
  • immune system phenotype
  • respiratory system phenotype
  • hematopoietic system phenotype
MGI:3042006Mapk3[tm1Jsw]Allele from Mouse Targeted (knock-out)
  • nervous system phenotype
  • behavior/neurological phenotype
MGI:3623480Mapk3[tm1Tgf]Allele from Mouse Targeted (knock-out)
  • immune system phenotype
MGI:4436235Mapk3[tm1e(EUCOMM)Hmgu]Mutant from cell lines34083
-
MGI:4436447Mapk3[tm1a(EUCOMM)Hmgu]Mutant from cell lines34083
-