AutismKB

Annotation Detail for MAPK1


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Basic Information Top
Gene Symbol:MAPK1 ( ERK,ERK2,ERT1,MAPK2,P42MAPK,PRKM1,PRKM2,p38,p40,p41,p41mapk )
Gene Full Name: mitogen-activated protein kinase 1
Band: 22q11.2|22q11.21
Quick LinksEntrez ID:5594; OMIM: 176948; Uniprot ID:MK01_HUMAN; ENSEMBL ID: ENSG00000100030
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005625IEA-soluble fraction-
GO:0005626IEA-insoluble fraction-
GO:0005634IEA-nucleus-
GO:0005654EXP-nucleoplasm16456541
GO:0005654TAS-nucleoplasm-
GO:0005737IEA-cytoplasm-
GO:0005829EXP-cytosol12832467
GO:0005829TAS-cytosol-
GO:0032839IEA-dendrite cytoplasm-
GO:0033267IEA-axon part-
GO:0043204IEA-perikaryon-
GO:0043234IEA-protein complex-
GO ID Evidence Qualifier GO_term References
GO:0000166IEA-nucleotide binding-
GO:0001784IEA-phosphotyrosine binding-
GO:0003677IEA-DNA binding-
GO:0004674EXP-protein serine/threonine kinase activity16626623
GO:0004707IEA-MAP kinase activity-
GO:0005515IPI-protein binding9632734
GO:0005524IEA-ATP binding-
GO:0008134IEA-transcription factor binding-
GO:0008353ISS-RNA polymerase II carboxy-terminal domain kinase activity-
GO:0016301EXP-kinase activity12832467
GO:0016301TAS-kinase activity-
GO:0019902IPI-phosphatase binding19494114
GO:0031435IEA-mitogen-activated protein kinase kinase kinase binding-
GO ID Evidence Qualifier GO_term References
GO:0000165TAS-MAPKKK cascade-
GO:0000186TAS-activation of MAPKK activity-
GO:0000187TAS-activation of MAPK activity-
GO:0000189IEA-MAPK import into nucleus-
GO:0002224TAS-toll-like receptor signaling pathway-
GO:0002755EXP-MyD88-dependent toll-like receptor signaling pathway15276183
GO:0002755TAS-MyD88-dependent toll-like receptor signaling pathway-
GO:0002756EXP-MyD88-independent toll-like receptor signaling pathway15276183
GO:0002756TAS-MyD88-independent toll-like receptor signaling pathway-
GO:0006917TAS-induction of apoptosis10958679
GO:0006935TAS-chemotaxis10706854
GO:0006950TAS-response to stress10958679
GO:0006974IEA-response to DNA damage stimulus-
GO:0007049IEA-cell cycle-
GO:0007165IEA-signal transduction-
GO:0007173TAS-epidermal growth factor receptor signaling pathway-
GO:0007264EXP-small GTPase mediated signal transduction10712923
GO:0007265EXP-Ras protein signal transduction11520933
GO:0007268TAS-synaptic transmission-
GO:0007411TAS-axon guidance-
GO:0007596TAS-blood coagulation-
GO:0008063TAS-Toll signaling pathway-
GO:0008284IEA-positive regulation of cell proliferation-
GO:0008286TAS-insulin receptor signaling pathway-
GO:0009636IEA-response to toxin-
GO:0009887IEA-organ morphogenesis-
GO:0016310EXP-phosphorylation12832467
GO:0019233IEA-sensory perception of pain-
GO:0019858IEA-cytosine metabolic process-
GO:0030168TAS-platelet activation-
GO:0030335IEA-positive regulation of cell migration-
GO:0031663IEA-lipopolysaccharide-mediated signaling pathway-
GO:0032496IEA-response to lipopolysaccharide-
GO:0034130TAS-toll-like receptor 1 signaling pathway-
GO:0034134TAS-toll-like receptor 2 signaling pathway-
GO:0034138TAS-toll-like receptor 3 signaling pathway-
GO:0034142TAS-toll-like receptor 4 signaling pathway-
GO:0043330IEA-response to exogenous dsRNA-
GO:0043627IEA-response to estrogen stimulus-
GO:0044419IEA-interspecies interaction between organisms-
GO:0045087TAS-innate immune response-
GO:0045596IEA-negative regulation of cell differentiation-
GO:0045727IEA-positive regulation of translation-
GO:0048011TAS-nerve growth factor receptor signaling pathway-
GO:0050852IEA-T cell receptor signaling pathway-
GO:0050853IEA-B cell receptor signaling pathway-
GO:0051090TAS-regulation of sequence-specific DNA binding transcription factor activity-
GO:0051403TAS-stress-activated MAPK cascade-
GO:0060716IEA-labyrinthine layer blood vessel development-
GO:0070371TAS-ERK1 and ERK2 cascade-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
MAPK1ALK10673914968112 Affinity Capture-MS
MAPK1ALK11158014968112 Affinity Capture-MS
MAPK1AR11158010318905 Reconstituted Complex
MAPK1AR10686210318905 Reconstituted Complex
MAPK1ARRB211158015699045 Affinity Capture-Western
MAPK1ARRB210690215699045 Affinity Capture-Western
MAPK1ATP1A111158015069082 Biochemical Activity
MAPK1ATP1A110696615069082 Biochemical Activity
MAPK1C1QBP11158011866440 Biochemical Activity
MAPK1C1QBP10716911866440 Biochemical Activity
MAPK1CASP911158012792650 Biochemical Activity
MAPK1CASP910729212792650 Biochemical Activity
MAPK1CDC25C11158016582626 Affinity Capture-Western; Reconstituted Complex
MAPK1CDC25C10743016582626 Affinity Capture-Western; Reconstituted Complex
MAPK1CEBPB11158011500490 Biochemical Activity
MAPK1CEBPB10748011500490 Biochemical Activity
MAPK1CENPE1074919744883 Affinity Capture-Western; Biochemical Activity
MAPK1CENPE1115809744883 Affinity Capture-Western; Biochemical Activity
MAPK1ATF21077767737129 Biochemical Activity
MAPK1ATF21115807737129 Biochemical Activity
MAPK1MAPK1410781911157753 12697810 Affinity Capture-Western
MAPK1MAPK1411158011157753 12697810 Affinity Capture-Western
MAPK1DUSP110817611278799 18519678 Affinity Capture-Western; Two-hybrid
MAPK1DUSP111158011278799 18519678 Affinity Capture-Western; Two-hybrid
MAPK1DUSP310817810224087 Affinity Capture-Western; Biochemical Activity
MAPK1DUSP311158010224087 Affinity Capture-Western; Biochemical Activity
MAPK1DUSP61081819535927 Reconstituted Complex
MAPK1DUSP61115809535927 Reconstituted Complex
MAPK1ELK11115808586671 10644696 12594221 Biochemical Activity; Reconstituted Complex
MAPK1ELK11083178586671 10644696 12594221 Biochemical Activity; Reconstituted Complex
MAPK1EP30010834717623675 Affinity Capture-Western; Biochemical Activity
MAPK1EP30011158017623675 Affinity Capture-Western; Biochemical Activity
MAPK1ESR110840311358671 12093745 Biochemical Activity; Reconstituted Complex
MAPK1ESR111158011358671 12093745 Biochemical Activity; Reconstituted Complex
MAPK1ESR210840411358671 Biochemical Activity
MAPK1ESR211158011358671 Biochemical Activity
MAPK1FHL211158014729955 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
MAPK1FHL210856514729955 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
MAPK1FOS10863611431474 Affinity Capture-Western
MAPK1FOS11158011431474 Affinity Capture-Western
MAPK1GATA410889611585926 Biochemical Activity
MAPK1GATA411158011585926 Biochemical Activity
MAPK1MKNK21115809155017 12897141 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
MAPK1MKNK21091309155017 12897141 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
MAPK1HMMR10940411403955 Affinity Capture-Western
MAPK1HMMR11158011403955 Affinity Capture-Western
MAPK1INSR10985411409918 Affinity Capture-Western
MAPK1INSR11158011409918 Affinity Capture-Western
MAPK1JUN10992811431474 Affinity Capture-Western
MAPK1JUN11158011431474 Affinity Capture-Western
MAPK1JUND10993016264271 Affinity Capture-Western
MAPK1JUND11158016264271 Affinity Capture-Western
MAPK1KRT811005411788583 Biochemical Activity
MAPK1KRT811158011788583 Biochemical Activity
MAPK1MAP3K111037810969079 Affinity Capture-Western
MAPK1MAP3K111158010969079 Affinity Capture-Western
MAPK1CIITA11041618245089 Affinity Capture-Western; Biochemical Activity
MAPK1CIITA11158018245089 Affinity Capture-Western; Biochemical Activity
MAPK1MYC1106947957875 9207092 15210690 Biochemical Activity; Reconstituted Complex
MAPK1MYC1115807957875 9207092 15210690 Biochemical Activity; Reconstituted Complex
MAPK1NEK211082615358203 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
MAPK1NEK211158015358203 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
MAPK1PEBP111107610757792 Reconstituted Complex
MAPK1PEBP111158010757792 Reconstituted Complex
MAPK1PECAM111120110801826 Affinity Capture-Western
MAPK1PECAM111158010801826 Affinity Capture-Western
MAPK1PGR11126017081988 Affinity Capture-Western
MAPK1PGR11158017081988 Affinity Capture-Western
MAPK1PRKCE11156711350735 Affinity Capture-Western
MAPK1PRKCE11158011350735 Affinity Capture-Western
THMAPK11115801347949 Biochemical Activity
THMAPK11129121347949 Biochemical Activity
VAV1MAPK11132528900182 9013873 Affinity Capture-Western
VAV1MAPK11115808900182 9013873 Affinity Capture-Western
RPS6KA2MAPK11115808939914 12832467 Affinity Capture-Western
RPS6KA2MAPK11121108939914 12832467 Affinity Capture-Western
RPS6KA3MAPK11121118939914 9915826 Affinity Capture-Western
RPS6KA3MAPK11115808939914 9915826 Affinity Capture-Western
MKNK1MAPK11115809155017 Reconstituted Complex; Two-hybrid
MKNK1MAPK11141389155017 Reconstituted Complex; Two-hybrid
RPS6KA5MAPK11115809687510 Phenotypic Enhancement
RPS6KA5MAPK11146769687510 Phenotypic Enhancement
PTPRRMAPK11115809857190 Reconstituted Complex
PTPRRMAPK11117659857190 Reconstituted Complex
PTPN5MAPK11115809857190 Reconstituted Complex
PTPN5MAPK11243129857190 Reconstituted Complex
RPS6KA1MAPK11115809915826 12594221 12832467 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
RPS6KA1MAPK11121099915826 12594221 12832467 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
STAT5AMAPK111265310194762 10996427 Affinity Capture-Western; Reconstituted Complex
STAT5AMAPK111158010194762 10996427 Affinity Capture-Western; Reconstituted Complex
PTPN7MAPK111174310206983 10702794 Affinity Capture-Western; Biochemical Activity
PTPN7MAPK111158010206983 10702794 Affinity Capture-Western; Biochemical Activity
TOP2AMAPK111158010207078 Biochemical Activity; Reconstituted Complex
TOP2AMAPK111300610207078 Biochemical Activity; Reconstituted Complex
SREBF1MAPK111259810627507 Biochemical Activity
SREBF1MAPK111158010627507 Biochemical Activity
SREBF2MAPK111259910627507 Biochemical Activity
SREBF2MAPK111158010627507 Biochemical Activity
MAP2K1MAPK111158010757792 11266467 11279118 11352917 11823456 12697810 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex; Two-hybrid
MAP2K1MAPK111159010757792 11266467 11279118 11352917 11823456 12697810 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex; Two-hybrid
DYRK1BMAPK111158010910078 Biochemical Activity
DYRK1BMAPK111459610910078 Biochemical Activity
TP53MAPK111158010958792 Affinity Capture-Western
TP53MAPK111301010958792 Affinity Capture-Western
TNKS2MAPK111158010988299 Biochemical Activity
TNKS2MAPK112325710988299 Biochemical Activity
SHC1MAPK111158010996427 Affinity Capture-Western
SHC1MAPK111236110996427 Affinity Capture-Western
HDAC4MAPK111158011114188 Affinity Capture-Western; Biochemical Activity
HDAC4MAPK111510611114188 Affinity Capture-Western; Biochemical Activity
MAPKSP1MAPK111158011266467 Reconstituted Complex
MAPKSP1MAPK111420111266467 Reconstituted Complex
DUSP22MAPK111158011346645 Affinity Capture-Western; Biochemical Activity
DUSP22MAPK112126411346645 Affinity Capture-Western; Biochemical Activity
RAF1MAPK111183111409918 Affinity Capture-Western
RAF1MAPK111158011409918 Affinity Capture-Western
DUSP16MAPK111158011489891 Affinity Capture-Western
DUSP16MAPK112332111489891 Affinity Capture-Western
PEA15MAPK111158011702783 Reconstituted Complex; Two-hybrid
PEA15MAPK111423011702783 Reconstituted Complex; Two-hybrid
MAP2K2MAPK111158011823456 Two-hybrid
MAP2K2MAPK111159111823456 Two-hybrid
SPRY2MAPK111158011983899 Affinity Capture-Western
SPRY2MAPK111554711983899 Affinity Capture-Western
ADAM17MAPK111273112058067 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
ADAM17MAPK111158012058067 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
SNCAMAPK111250612121974 Affinity Capture-Western
SNCAMAPK111158012121974 Affinity Capture-Western
SNCGMAPK111158012121974 Affinity Capture-Western
SNCGMAPK111250712121974 Affinity Capture-Western
TOB1MAPK111544312151396 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex; Two-hybrid
TOB1MAPK111158012151396 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex; Two-hybrid
TNIP1MAPK111158012220502 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
TNIP1MAPK111560212220502 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
IER3MAPK111439012356731 Biochemical Activity
IER3MAPK111158012356731 Biochemical Activity
UBR5MAPK111158012594221 Affinity Capture-Western; Biochemical Activity
UBR5MAPK111950112594221 Affinity Capture-Western; Biochemical Activity
TPRMAPK111158012594221 Biochemical Activity
TPRMAPK111302812594221 Biochemical Activity
MAPKAPK2MAPK111158015094067 Affinity Capture-Western
MAPKAPK2MAPK111468315094067 Affinity Capture-Western
SORBS3MAPK111158015184391 Affinity Capture-Western; Biochemical Activity
SORBS3MAPK111547515184391 Affinity Capture-Western; Biochemical Activity
TSC2MAPK111158015851026 Affinity Capture-Western; Reconstituted Complex
TSC2MAPK111310015851026 Affinity Capture-Western; Reconstituted Complex
TFCP2MAPK111158015857981 Biochemical Activity
TFCP2MAPK111288215857981 Biochemical Activity
UBCMAPK111158017327227 Affinity Capture-Western
UBCMAPK111316417327227 Affinity Capture-Western
ARHGEF2MAPK111158018211802 Affinity Capture-Western
ARHGEF2MAPK111461818211802 Affinity Capture-Western
MTPNMAPK111158020936779 Two-hybrid
MTPNMAPK112645520936779 Two-hybrid
Gene Symbol Interactant Interaction ID References Description
RB1MAPK118223615489336 RB1 is phosphorylated by MAPK1. This interaction was modeled on a demonstrated interaction between human KIAA1536 and MAPK1 from an unspecified species.
CALCOCO1MAPK118223515489336 KIAA1536 is phosphorylated by MAPK1. This interaction was modeled on a demonstrated interaction between human KIAA1536 and MAPK1 from an unspecified species.
No data
Genomic Variants Top
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:1346858
  • Data Attributes: MGI curated and HomoloGene calculated
MGI Allele ID Allele Symbol Allele Source Allele Type / Mutant Cell line ID
MGI:2683190Mapk1[tm1Melo]Allele from Mouse Targeted (knock-out)
  • muscle phenotype
  • liver/biliary system phenotype
  • homeostasis/metabolism phenotype
  • growth/size phenotype
  • embryogenesis phenotype
  • cellular phenotype
  • cardiovascular system phenotype
  • respiratory system phenotype
MGI:3055889Mapk1[tm1Moga]Allele from Mouse Targeted (knock-out)
  • growth/size phenotype
  • embryogenesis phenotype
  • cardiovascular system phenotype
MGI:3055890Mapk1[tm2Moga]Allele from Mouse Targeted (knock-out)
  • growth/size phenotype
  • embryogenesis phenotype
  • cardiovascular system phenotype
  • immune system phenotype
  • hematopoietic system phenotype
MGI:3686887Mapk1[tm1Hed]Allele from Mouse Targeted (Floxed/Frt)
  • immune system phenotype
  • hematopoietic system phenotype
MGI:3686888Mapk1[tm1.1Hed]Allele from Mouse Targeted (Floxed/Frt)
  • homeostasis/metabolism phenotype
  • immune system phenotype
  • hematopoietic system phenotype
MGI:3686889Mapk1[tm2Hed]Allele from Mouse Targeted (knock-out)
  • reproductive system phenotype
MGI:3759774Mapk1[tm1Kuta]Allele from Mouse Targeted (Floxed/Frt)
  • nervous system phenotype
  • behavior/neurological phenotype
MGI:3759775Mapk1[tm1.1Kuta]Allele from Mouse Targeted (knock-out)
  • growth/size phenotype
MGI:3803954Mapk1[tm1Gela]Allele from Mouse Targeted (Floxed/Frt)
  • nervous system phenotype
  • behavior/neurological phenotype
MGI:4820400Mapk1[tm2Melo]Allele from Mouse Targeted (Floxed/Frt)
  • cellular phenotype
MGI:4432537Mapk1[tm1a(EUCOMM)Wtsi]Mutant from cell lines23334
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