AutismKB

Annotation Detail for NLGN3


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Basic Information Top
Gene Symbol:NLGN3 ( HNL3,KIAA1480 )
Gene Full Name: neuroligin 3
Band: Xq13.1
Quick LinksEntrez ID:54413; OMIM: 300336; Uniprot ID:NLGN3_HUMAN; ENSEMBL ID: ENSG00000196338
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005737IDA-cytoplasm18029348
GO:0005887ISS-integral to plasma membrane-
GO:0009986IDA-cell surface15150161
GO:0016020IEA-membrane-
GO:0030139ISS-endocytic vesicle-
GO:0045202ISS-synapse-
GO ID Evidence Qualifier GO_term References
GO:0004091ISS-carboxylesterase activity-
GO:0004872ISS-receptor activity-
GO:0005515IPI-protein binding17292328
GO ID Evidence Qualifier GO_term References
GO:0006898ISS-receptor-mediated endocytosis-
GO:0007155IEA-cell adhesion-
GO:0007158ISS-neuron cell-cell adhesion-
GO:0007416ISS-synapse assembly-
GO:0035176IMP-social behavior12669065
GO:0050804ISS-regulation of synaptic transmission-
GO:0050808IMP-synapse organization15150161
GO:0051965ISS-positive regulation of synaptogenesis-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
NLGN3DLG21080849278515 Two-hybrid
NLGN3DLG21199449278515 Two-hybrid
NLGN3DLG31199449278515 Two-hybrid
NLGN3DLG31080859278515 Two-hybrid
NLGN3DLG41199449278515 Two-hybrid
NLGN3DLG41080869278515 Two-hybrid
NLGN3NRXN31147708576240 Reconstituted Complex
NLGN3NRXN31199448576240 Reconstituted Complex
NLGN3NRXN11147798576240 Reconstituted Complex
NLGN3NRXN11199448576240 Reconstituted Complex
No data
No data
Genomic Variants Top
Variant ID Location Publication Method/platform Gain Lose Total Frequency Sample Size Genes
Variation_7797 chrX:69557260-71024758 17666407 Agilent 185k CGH Arrays/Agilent Custom CGH Arrays 0 5 5- 50 control samples (French) INGX, GDPD2, SLC7A3, OGT, FLJ46446, NLGN3, KIF4A, NONO, TEX11, CXorf49, FOXO4, MED12, SNX12, CXorf49B, LOC100132741, DLG3, TAF1, ZMYM3, ITGB1BP2, CXCR3, CXorf65, ACRC, IL2RG, GJB1
Variation_74003 chrX:70292327-70293467 19812545 NimbleGen custom 42M oligo array CGH 1 0 1 NA 39 HapMap Individuals + NA15510 NLGN3
No data
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:2444609
  • Data Attributes: MGI curated and HomoloGene calculated
MGI Allele ID Allele Symbol Allele Source Allele Type / Mutant Cell line ID
MGI:3687640Nlgn3[tm1Bros]Allele from Mouse Targeted (knock-out)
  • nervous system phenotype
  • growth/size phenotype
  • behavior/neurological phenotype
  • respiratory system phenotype
  • reproductive system phenotype
  • taste/olfaction phenotype
MGI:3758949Nlgn3[tm1Sud]Allele from Mouse Targeted (knock-in)
  • nervous system phenotype
  • behavior/neurological phenotype
MGI:3758960Nlgn3[tm2.1Sud]Allele from Mouse Targeted (knock-out)
  • normal phenotype
MGI:3796212Nlgn3[tm1(KOMP)Vlcg]Mutant from cell linesVG10013
-
MGI:4458864Nlgn3[tm1a(EUCOMM)Wtsi]Mutant from cell lines78893
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