AutismKB

Annotation Detail for MECP2


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Basic Information Top
Gene Symbol:MECP2 ( AUTSX3,DKFZp686A24160,MRX16,MRX79,MRXS13,MRXSL,PPMX,RS,RTS,RTT )
Gene Full Name: methyl CpG binding protein 2 (Rett syndrome)
Band: Xq28
Quick LinksEntrez ID:4204; OMIM: 300005; Uniprot ID:MECP2_HUMAN; ENSEMBL ID: ENSG00000169057
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0000792IDA-heterochromatin11441023
GO:0005634IDA-nucleus18029348
GO ID Evidence Qualifier GO_term References
GO:0003677IEA-DNA binding-
GO:0003714TAS-transcription corepressor activity10773092
GO:0005515IPI-protein binding15696166
GO:0010385IMP-double-stranded methylated DNA binding17296936
GO:0019904IPI-protein domain specific binding11441023
GO:0047485IPI-protein N-terminus binding11441023
GO ID Evidence Qualifier GO_term References
GO:0000122TAS-negative regulation of transcription from RNA polymerase II promoter9620804
GO:0045892IDA-negative regulation of transcription, DNA-dependent11441023
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
MECP2DNMT110812312473678 Affinity Capture-Western; Reconstituted Complex
MECP2DNMT111036812473678 Affinity Capture-Western; Reconstituted Complex
MECP2GTF2B10921410756192 Reconstituted Complex
MECP2GTF2B11036810756192 Reconstituted Complex
MECP2HDAC110931512473678 14593184 14647463 16331260 Affinity Capture-Western; Reconstituted Complex
MECP2HDAC111036812473678 14593184 14647463 16331260 Affinity Capture-Western; Reconstituted Complex
MECP2HMGB111036811748221 Reconstituted Complex
MECP2HMGB110938911748221 Reconstituted Complex
MECP2RBPJ10973616763620 Affinity Capture-Western
MECP2RBPJ11036816763620 Affinity Capture-Western
MECP2LBR11012219331822 Affinity Capture-Western; Co-fractionation; Co-localization; Reconstituted Complex
MECP2LBR11036819331822 Affinity Capture-Western; Co-fractionation; Co-localization; Reconstituted Complex
PRPF40AMECP21103689171351 14618241 Affinity Capture-Western; Far Western; Reconstituted Complex
PRPF40AMECP21207929171351 14618241 Affinity Capture-Western; Far Western; Reconstituted Complex
SIN3BMECP21169019620779 Affinity Capture-Western
SIN3BMECP21103689620779 Affinity Capture-Western
SIN3AMECP21174399620779 9620804 10773092 14593184 15322089 Affinity Capture-Western; Reconstituted Complex
SIN3AMECP21103689620779 9620804 10773092 14593184 15322089 Affinity Capture-Western; Reconstituted Complex
SKIMECP211036811441023 Affinity Capture-Western; Reconstituted Complex
SKIMECP211238811441023 Affinity Capture-Western; Reconstituted Complex
NCOR1MECP211497311441023 Reconstituted Complex
NCOR1MECP211036811441023 Reconstituted Complex
RCOR1MECP211679612399542 Affinity Capture-Western
RCOR1MECP211036812399542 Affinity Capture-Western
SUV39H1MECP211270612399542 Affinity Capture-Western
SUV39H1MECP211036812399542 Affinity Capture-Western
HIST2H3AMECP213061612427740 Reconstituted Complex
HIST2H3AMECP211036812427740 Reconstituted Complex
PRPF40BMECP211730514618241 Affinity Capture-Western; Reconstituted Complex
PRPF40BMECP211036814618241 Affinity Capture-Western; Reconstituted Complex
SPI1MECP211036814647463 16331260 Affinity Capture-Western; Reconstituted Complex
SPI1MECP211256614647463 16331260 Affinity Capture-Western; Reconstituted Complex
SP1MECP211036815109260 Affinity Capture-Western
SP1MECP211255015109260 Affinity Capture-Western
SMARCE1MECP211248915696166 Affinity Capture-Western
SMARCE1MECP211036815696166 Affinity Capture-Western
SMARCA2MECP211247915696166 Affinity Capture-Western; Reconstituted Complex
SMARCA2MECP211036815696166 Affinity Capture-Western; Reconstituted Complex
SMARCB1MECP211248215696166 Reconstituted Complex
SMARCB1MECP211036815696166 Reconstituted Complex
CDKL5MECP211266815917271 Affinity Capture-Western; Reconstituted Complex
CDKL5MECP211036815917271 Affinity Capture-Western; Reconstituted Complex
YBX1MECP211036816251272 Affinity Capture-Western
YBX1MECP211095916251272 Affinity Capture-Western
CBX5MECP211703017698499 Affinity Capture-Western
CBX5MECP211036817698499 Affinity Capture-Western
No data
No data
Genomic Variants Top
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:99918
  • Data Attributes: MGI curated and HomoloGene calculated
MGI Allele ID Allele Symbol Allele Source Allele Type / Mutant Cell line ID
MGI:2137311Mecp2[tm1.1Bird]Allele from Mouse Targeted (knock-out)
  • nervous system phenotype
  • adipose tissue phenotype
  • homeostasis/metabolism phenotype
  • hearing/vestibular/ear phenotype
  • growth/size phenotype
  • endocrine/exocrine gland phenotype
  • craniofacial phenotype
  • cellular phenotype
  • behavior/neurological phenotype
  • respiratory system phenotype
  • reproductive system phenotype
  • skeleton phenotype
MGI:2137555Mecp2[tm1Bird]Allele from Mouse Targeted (Floxed/Frt)
  • nervous system phenotype
  • hearing/vestibular/ear phenotype
  • growth/size phenotype
  • endocrine/exocrine gland phenotype
  • craniofacial phenotype
  • behavior/neurological phenotype
  • respiratory system phenotype
  • reproductive system phenotype
MGI:2158353Mecp2[tm1Jae]Allele from Mouse Targeted (Floxed/Frt)
  • nervous system phenotype
  • growth/size phenotype
  • behavior/neurological phenotype
  • respiratory system phenotype
MGI:2158354Mecp2[tm1.1Jae]Allele from Mouse Targeted (knock-out)
  • nervous system phenotype
  • homeostasis/metabolism phenotype
  • growth/size phenotype
  • behavior/neurological phenotype
  • respiratory system phenotype
MGI:2183727Mecp2[tm1Hzo]Allele from Mouse Targeted (knock-out)
  • nervous system phenotype
  • cellular phenotype
  • behavior/neurological phenotype
  • skeleton phenotype
MGI:3583768Mecp2[tm1Jchr]Allele from Mouse Targeted (knock-out)
  • behavior/neurological phenotype
MGI:3700191Mecp2[tm2Bird]Allele from Mouse Targeted (Floxed/Frt)
  • nervous system phenotype
  • growth/size phenotype
  • behavior/neurological phenotype
  • respiratory system phenotype
MGI:3797096Mecp2[tm1Csb]Allele from Mouse Targeted (Reporter)
  • no phenotypic analysis
MGI:3800596Mecp2[tm1Pplt]Allele from Mouse Targeted (knock-out)
  • nervous system phenotype
  • growth/size phenotype
  • craniofacial phenotype
  • behavior/neurological phenotype
  • respiratory system phenotype
  • skeleton phenotype
MGI:3840524Mecp2[tm2Jae]Allele from Mouse Targeted (Floxed/Frt)
  • no phenotypic analysis
MGI:3840525Mecp2[tm3.1Jae]Allele from Mouse Targeted (knock-in)
  • nervous system phenotype
  • behavior/neurological phenotype
MGI:3840527Mecp2[tm2.1Jae]Allele from Mouse Targeted (knock-in)
  • growth/size phenotype
  • behavior/neurological phenotype
MGI:4434266Mecp2[tm1a(EUCOMM)Wtsi]Mutant from cell lines26615
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