AutismKB

Annotation Detail for HPRT1


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Basic Information Top
Gene Symbol:HPRT1 ( HGPRT,HPRT )
Gene Full Name: hypoxanthine phosphoribosyltransferase 1
Band: Xq26.1
Quick LinksEntrez ID:3251; OMIM: 308000; Uniprot ID:HPRT_HUMAN; ENSEMBL ID: ENSG00000165704
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005625IEA-soluble fraction-
GO:0005737IDA-cytoplasm18029348
GO:0005829EXP-cytosol6300847
GO ID Evidence Qualifier GO_term References
GO:0000166IEA-nucleotide binding-
GO:0000287IDA-magnesium ion binding10360366
GO:0004422EXP-hypoxanthine phosphoribosyltransferase activity6300847
GO:0004422IDA-hypoxanthine phosphoribosyltransferase activity19527031
GO:0004614ISSNOTphosphoglucomutase activity-
GO:0005515IPI-protein binding17353931
GO:0016757IEA-transferase activity, transferring glycosyl groups-
GO:0042803IPI-protein homodimerization activity8044844
GO:0052657IDA-guanine phosphoribosyltransferase activity19527031
GO ID Evidence Qualifier GO_term References
GO:0001975ISS-response to amphetamine-
GO:0006144TAS-purine base metabolic process-
GO:0006164IMP-purine nucleotide biosynthetic process9824441
GO:0006166IMP-purine ribonucleoside salvage9824441
GO:0006168ISS-adenine salvage-
GO:0006178IDA-guanine salvage19527031
GO:0007283IEA-spermatogenesis-
GO:0007610IMP-behavior16138897
GO:0007625ISS-grooming behavior-
GO:0009116IEA-nucleoside metabolic process-
GO:0019255ISSNOTglucose 1-phosphate metabolic process-
GO:0019835ISS-cytolysis-
GO:0021756ISS-striatum development-
GO:0021895ISS-cerebral cortex neuron differentiation-
GO:0021954ISS-central nervous system neuron development-
GO:0032263ISS-GMP salvage-
GO:0032264ISS-IMP salvage-
GO:0043101TAS-purine-containing compound salvage-
GO:0043103IDA-hypoxanthine salvage19527031
GO:0045964IMP-positive regulation of dopamine metabolic process8643611
GO:0046038IDA-GMP catabolic process19527031
GO:0046040IDA-IMP metabolic process19527031
GO:0046083IEA-adenine metabolic process-
GO:0046100IMP-hypoxanthine metabolic process9824441
GO:0046651ISS-lymphocyte proliferation-
GO:0048813ISS-dendrite morphogenesis-
GO:0051289IDA-protein homotetramerization9521733
GO:0051289IPI-protein homotetramerization15990111
GO:0055086TAS-nucleobase, nucleoside and nucleotide metabolic process-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
HPRT1FANCA10948814499622 Two-hybrid
HPRT1FANCA10847214499622 Two-hybrid
WDYHV1HPRT110948816189514 Two-hybrid
WDYHV1HPRT112040516189514 Two-hybrid
PRTFDC1HPRT110948816189514 Two-hybrid
PRTFDC1HPRT112127616189514 Two-hybrid
EIF1BHPRT111557817353931 Affinity Capture-MS
EIF1BHPRT110948817353931 Affinity Capture-MS
HUS1HPRT110948817353931 Affinity Capture-MS
HUS1HPRT110959617353931 Affinity Capture-MS
MCCHPRT110948817353931 Affinity Capture-MS
MCCHPRT111033317353931 Affinity Capture-MS
No data
No data
Genomic Variants Top
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:96217
  • Data Attributes: MGI curated and HomoloGene calculated
MGI Allele ID Allele Symbol Allele Source Allele Type / Mutant Cell line ID
MGI:1857297Hprt[b-m1]Allele from Mouse Transgenic (random, gene disruption)
  • nervous system phenotype
  • behavior/neurological phenotype
MGI:1857298Hprt[b-m2]Allele from Mouse Transgenic (random, gene disruption)
  • nervous system phenotype
  • behavior/neurological phenotype
MGI:1857299Hprt[b-m3]Allele from Mouse Spontaneous
  • normal phenotype
  • nervous system phenotype
  • behavior/neurological phenotype
  • immune system phenotype
  • hematopoietic system phenotype
MGI:1861939Hprt[tm1Detl]Allele from Mouse Targeted (knock-in)
  • nervous system phenotype
  • liver/biliary system phenotype
  • growth/size phenotype
  • endocrine/exocrine gland phenotype
  • behavior/neurological phenotype
  • reproductive system phenotype
MGI:2181632Hprt[tm1(cre)Mnn]Allele from Mouse Targeted (knock-in)
  • pigmentation phenotype
  • no phenotypic analysis
  • homeostasis/metabolism phenotype
  • embryogenesis phenotype
  • behavior/neurological phenotype
  • vision/eye phenotype
MGI:2386181Hprt[tm1(Tek-lacZ)Rdr]Allele from Mouse Targeted (knock-in)
  • no phenotypic analysis
MGI:2447168Hprt[tm1(FLT1-lacZ)Aird]Allele from Mouse Targeted (knock-in)
  • no phenotypic analysis
MGI:2447169Hprt[tm2(VWF-lacZ)Aird]Allele from Mouse Targeted (knock-in)
  • no phenotypic analysis
MGI:2449451Hprt[tm1(AGT)Sig]Allele from Mouse Targeted (knock-in)
  • cardiovascular system phenotype
MGI:2449453Hprt[tm2(AGT)Sig]Allele from Mouse Targeted (knock-in)
  • cardiovascular system phenotype
MGI:2450106Hprt[tm1(ACTB-Epor)Unc]Allele from Mouse Targeted (knock-in)
  • hematopoietic system phenotype
MGI:2668517Hprt[tm2Detl]Allele from Mouse Targeted (knock-in)
  • nervous system phenotype
  • behavior/neurological phenotype
MGI:2668518Hprt[tm3Detl]Allele from Mouse Targeted (knock-in)
  • behavior/neurological phenotype
MGI:2668519Hprt[tm4Detl]Allele from Mouse Targeted (knock-in)
  • nervous system phenotype
  • behavior/neurological phenotype
MGI:2668520Hprt[tm5Detl]Allele from Mouse Targeted (knock-in)
  • behavior/neurological phenotype
MGI:2668521Hprt[tm6Detl]Allele from Mouse Targeted (knock-in)
  • nervous system phenotype
  • behavior/neurological phenotype
MGI:2668522Hprt[tm7Detl]Allele from Mouse Targeted (knock-in)
  • behavior/neurological phenotype
MGI:3046308Hprt[tm1(CMV-cre)Brd]Allele from Mouse Targeted (knock-in)
  • nervous system phenotype
  • homeostasis/metabolism phenotype
  • endocrine/exocrine gland phenotype
MGI:3046925Hprt[tm1(UAS-Bmp4)Bhr]Allele from Mouse Targeted (knock-in)
  • nervous system phenotype
  • growth/size phenotype
  • embryogenesis phenotype
  • cardiovascular system phenotype
MGI:3046927Hprt[tm2(UAS-Bmp4)Bhr]Allele from Mouse Targeted (knock-in)
  • nervous system phenotype
  • growth/size phenotype
  • embryogenesis phenotype
  • cardiovascular system phenotype
  • vision/eye phenotype
MGI:3050087Hprt[tm1Dhm]Allele from Mouse Targeted (knock-in)
  • muscle phenotype
  • cardiovascular system phenotype
MGI:3051543Hprt[tm1(Ggt1-Agtr1)Cof]Allele from Mouse Targeted (knock-in)
  • normal phenotype
  • renal/urinary system phenotype
  • homeostasis/metabolism phenotype
  • cardiovascular system phenotype
MGI:3582525Hprt[tm1Pobe]Allele from Mouse Targeted (Floxed/Frt)
  • no phenotypic analysis
MGI:3582526Hprt[tm1.1Pobe]Allele from Mouse Targeted (knock-out)
  • normal phenotype
MGI:3582838Hprt[tm2(Pgk1-Pac/Tk)Brd]Allele from Mouse Targeted (knock-in)
  • normal phenotype
  • nervous system phenotype
  • homeostasis/metabolism phenotype
  • growth/size phenotype
  • embryogenesis phenotype
  • craniofacial phenotype
  • cardiovascular system phenotype
  • reproductive system phenotype
MGI:3621174Hprt[tm1(Pck1-cre)Vhh]Allele from Mouse Targeted (knock-in)
  • tumorigenesis
  • renal/urinary system phenotype
  • muscle phenotype
  • liver/biliary system phenotype
  • homeostasis/metabolism phenotype
  • cellular phenotype
  • cardiovascular system phenotype
  • immune system phenotype
  • hematopoietic system phenotype
MGI:3662639Hprt[tm2(ACTB-GFP)Unc]Allele from Mouse Targeted (knock-in)
  • no phenotypic analysis
MGI:3662641Hprt[tm3(ACTB-GFP)Unc]Allele from Mouse Targeted (knock-in)
  • no phenotypic analysis
MGI:3662642Hprt[tm4(ACTB-GFP)Unc]Allele from Mouse Targeted (knock-in)
  • no phenotypic analysis
MGI:3687214Hprt[tm1(CUX1)Anep]Allele from Mouse Targeted (knock-in)
  • tumorigenesis
  • liver/biliary system phenotype
  • endocrine/exocrine gland phenotype
  • immune system phenotype
  • respiratory system phenotype
  • reproductive system phenotype
  • hematopoietic system phenotype
MGI:3697440Hprt[tm1Isrd]Allele from Mouse Targeted (knock-in)
  • normal phenotype
MGI:3702333Hprt[tm1(Penk1-lacZ)Saub]Allele from Mouse Targeted (Reporter)
  • no phenotypic analysis
MGI:3702336Hprt[tm2(Penk1-lacZ)Saub]Allele from Mouse Targeted (Reporter)
  • no phenotypic analysis
MGI:3715138Hprt[tm1(UbC-UBB)Rrk]Allele from Mouse Targeted (knock-in)
  • liver/biliary system phenotype
  • growth/size phenotype
  • embryogenesis phenotype
  • cellular phenotype
MGI:3776893Hprt[tm1Brd]Allele from Mouse Targeted (Floxed/Frt)
  • no phenotypic analysis
MGI:3776895Hprt[tm2Brd]Allele from Mouse Targeted (Reporter)
  • hearing/vestibular/ear phenotype
MGI:3776896Hprt[tm3Brd]Allele from Mouse Targeted (knock-in)
  • hearing/vestibular/ear phenotype
MGI:3785623Hprt[tm1(HP)Mae]Allele from Mouse Targeted (knock-in)
  • no phenotypic analysis
MGI:3803282Hprt[tm3(ROBO4-lacZ)Aird]Allele from Mouse Targeted (Reporter)
  • no phenotypic analysis
MGI:3808842Hprt[tm4(ROBO4*-lacZ)Aird]Allele from Mouse Targeted (knock-in)
  • no phenotypic analysis
MGI:3815189Hprt[tm1Cjo]Allele from Mouse Targeted (Reporter)
  • normal phenotype
MGI:3830628Hprt[tm4(Ple88-EGFP)Ems]Allele from Mouse Targeted (knock-in)
  • normal phenotype
MGI:3830629Hprt[tm7(Ple185-EGFP)Ems]Allele from Mouse Targeted (knock-in)
  • normal phenotype
MGI:3830630Hprt[tm8(Ple151-EGFP)Ems]Allele from Mouse Targeted (knock-in)
  • normal phenotype
MGI:3831277Hprt[tm1(Pbsn*-cre/ERT2)Jir]Allele from Mouse Targeted (knock-in)
  • tumorigenesis
  • normal phenotype
MGI:3832668Hprt[tm1(AGT)Asku]Allele from Mouse Targeted (knock-in)
  • homeostasis/metabolism phenotype
  • cardiovascular system phenotype
MGI:3832669Hprt[tm2(AGT)Asku]Allele from Mouse Targeted (knock-in)
  • homeostasis/metabolism phenotype
  • cardiovascular system phenotype
MGI:3835520Hprt[tm9(Ple178-EGFP/cre)Ems]Allele from Mouse Targeted (knock-in)
  • normal phenotype
MGI:3835521Hprt[tm10(Ple162-EGFP/cre)Ems]Allele from Mouse Targeted (knock-in)
  • normal phenotype
MGI:3835522Hprt[tm11(Ple176-EGFP/cre)Ems]Allele from Mouse Targeted (knock-in)
  • normal phenotype
MGI:3835523Hprt[tm12(Ple177-EGFP/cre)Ems]Allele from Mouse Targeted (knock-in)
  • normal phenotype
MGI:3835524Hprt[tm13(Ple54-EGFP)Ems]Allele from Mouse Targeted (knock-in)
  • normal phenotype
MGI:3835525Hprt[tm14(Ple103-EGFP/cre)Ems]Allele from Mouse Targeted (knock-in)
  • normal phenotype
MGI:3835527Hprt[tm15(Ple111-EGFP)Ems]Allele from Mouse Targeted (knock-in)
  • normal phenotype
MGI:3835530Hprt[tm16(Ple167-EGFP/cre)Ems]Allele from Mouse Targeted (knock-in)
  • normal phenotype
MGI:3835531Hprt[tm18(Ple90-EGFP)Ems]Allele from Mouse Targeted (knock-in)
  • normal phenotype
MGI:3835532Hprt[tm17(Ple48-lacZ)Ems]Allele from Mouse Targeted (knock-in)
  • normal phenotype
MGI:3835533Hprt[tm19(Ple88-lacZ)Ems]Allele from Mouse Targeted (knock-in)
  • normal phenotype
MGI:3835534Hprt[tm20(Ple53-EGFP)Ems]Allele from Mouse Targeted (knock-in)
  • normal phenotype
MGI:3839278Hprt[tm1(APOA5)Lap]Allele from Mouse Targeted (knock-in)
  • homeostasis/metabolism phenotype
MGI:3839279Hprt[tm2(APOA5)Lap]Allele from Mouse Targeted (knock-in)
  • homeostasis/metabolism phenotype
MGI:3839280Hprt[tm3(APOA5)Lap]Allele from Mouse Targeted (knock-in)
  • homeostasis/metabolism phenotype
MGI:3846738Hprt[tm1(CAG-Tgfbr1*)Lba]Allele from Mouse Targeted (Floxed/Frt)
  • immune system phenotype
  • hematopoietic system phenotype
MGI:3850734Hprt[tm1(Rcan1)Zyga]Allele from Mouse Targeted (knock-in)
  • tumorigenesis
  • cardiovascular system phenotype
MGI:4359808Hprt[tm5(RCAN1-lacZ)Aird]Allele from Mouse Targeted (Reporter)
  • no phenotypic analysis
MGI:4360515Hprt[tm2(CUX1)Anep]Allele from Mouse Targeted (knock-in)
  • tumorigenesis
  • endocrine/exocrine gland phenotype
  • immune system phenotype
MGI:4437604Hprt[tm1(tetO-lacZ)Frje]Allele from Mouse Targeted (Reporter)
  • no phenotypic analysis
MGI:4437607Hprt[tm2(tetO-lacZ,-NR3C1)Frje]Allele from Mouse Targeted (Reporter)
  • no phenotypic analysis
MGI:4462242Hprt[tm1Dwm]Allele from Mouse Targeted (knock-in)
  • normal phenotype
MGI:4834648Hprt[tm31(Ple67-EGFP)Ems]Allele from Mouse Targeted (knock-in)
  • normal phenotype
MGI:4834653Hprt[tm32(Ple112-EGFP)Ems]Allele from Mouse Targeted (knock-in)
  • normal phenotype
MGI:4834776Hprt[tm33(Ple183-EGFP)Ems]Allele from Mouse Targeted (knock-in)
  • normal phenotype
MGI:4834777Hprt[tm37(lacZ)Ems]Allele from Mouse Targeted (knock-in)
  • normal phenotype
MGI:4834779Hprt[tm44(Ple49-lacZ)Ems]Allele from Mouse Targeted (knock-in)
  • normal phenotype
MGI:4834787Hprt[tm34(Ple186-EGFP)Ems]Allele from Mouse Targeted (Floxed/Frt)
  • normal phenotype
MGI:4834789Hprt[tm54(Ple233-EGFP)Ems]Allele from Mouse Targeted (knock-in)
  • normal phenotype
MGI:4834790Hprt[tm41(Ple160-lacZ)Ems]Allele from Mouse Targeted (knock-in)
  • normal phenotype
MGI:4834828Hprt[tm42(Ple131-lacZ)Ems]Allele from Mouse Targeted (knock-in)
  • normal phenotype
MGI:4834831Hprt[tm45(Ple67-lacZ)Ems]Allele from Mouse Targeted (knock-in)
  • normal phenotype
MGI:4834832Hprt[tm50(Ple55-lacZ)Ems]Allele from Mouse Targeted (knock-in)
  • normal phenotype
MGI:4834836Hprt[tm63(Ple12-lacZ)Ems]Allele from Mouse Targeted (knock-in)
  • normal phenotype
MGI:4834840Hprt[tm64(Ple170-lacZ)Ems]Allele from Mouse Targeted (knock-in)
  • normal phenotype
MGI:4834842Hprt[tm65(Ple53-lacZ)Ems]Allele from Mouse Targeted (knock-in)
  • normal phenotype
MGI:4834844Hprt[tm66(Ple5-lacZ)Ems]Allele from Mouse Targeted (knock-in)
  • normal phenotype
MGI:4834846Hprt[tm38(Ple17-lacZ)Ems]Allele from Mouse Targeted (knock-in)
  • normal phenotype
MGI:4834848Hprt[tm39(Ple24-lacZ)Ems]Allele from Mouse Targeted (knock-in)
  • normal phenotype
MGI:4834850Hprt[tm40(Ple34-lacZ)Ems]Allele from Mouse Targeted (knock-in)
  • normal phenotype
MGI:4834856Hprt[tm43(Ple140-lacZ)Ems]Allele from Mouse Targeted (knock-in)
  • normal phenotype
MGI:4834861Hprt[tm56(Ple25-lacZ)Ems]Allele from Mouse Targeted (knock-in)
  • normal phenotype
MGI:4834869Hprt[tm58(Ple119-lacZ)Ems]Allele from Mouse Targeted (knock-in)
  • normal phenotype
MGI:4834875Hprt[tm59(Ple123-lacZ)Ems]Allele from Mouse Targeted (knock-in)
  • normal phenotype
MGI:4834877Hprt[tm62(Ple153-lacZ)Ems]Allele from Mouse Targeted (knock-in)
  • normal phenotype
MGI:4834879Hprt[tm67(Ple238-lacZ)Ems]Allele from Mouse Targeted (knock-in)
  • normal phenotype
MGI:4834880Hprt[tm68(Ple127-lacZ)Ems]Allele from Mouse Targeted (knock-in)
  • normal phenotype
MGI:4834883Hprt[tm69(Ple134-lacZ)Ems]Allele from Mouse Targeted (knock-in)
  • normal phenotype
MGI:4834886Hprt[tm70(Ple240-lacZ)Ems]Allele from Mouse Targeted (knock-in)
  • normal phenotype
MGI:4834887Hprt[tm71(Ple155-lacZ)Ems]Allele from Mouse Targeted (knock-in)
  • normal phenotype
MGI:4834888Hprt[tm72(Ple158-lacZ)Ems]Allele from Mouse Targeted (knock-in)
  • normal phenotype
MGI:4835011Hprt[tm73(Ple142-lacZ)Ems]Allele from Mouse Targeted (knock-in)
  • normal phenotype
MGI:4835013Hprt[tm53(CAG-lacZ)Ems]Allele from Mouse Targeted (knock-in)
  • normal phenotype
MGI:4835014Hprt[tm74(Ple232-lacZ)Ems]Allele from Mouse Targeted (knock-in)
  • normal phenotype
MGI:4836990Hprt[tm57(Ple26-lacZ)Ems]Allele from Mouse Targeted (knock-in)
  • normal phenotype
MGI:4435169Hprt[tm1a(EUCOMM)Hmgu]Mutant from cell lines29303
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