Annotation Detail for TBX21

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Basic Information Top
Gene Symbol:TBX21 ( T-PET,T-bet,TBET,TBLYM )
Gene Full Name: T-box 21
Band: 17q21.32
Quick LinksEntrez ID:30009; OMIM: 604895; Uniprot ID:TBX21_HUMAN; ENSEMBL ID: ENSG00000073861
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0043025IEA-neuronal cell body-
GO ID Evidence Qualifier GO_term References
GO:0003677IEA-DNA binding-
GO:0003700TAS-sequence-specific DNA binding transcription factor activity10761931
GO:0044212IDA-transcription regulatory region DNA binding19805038
GO ID Evidence Qualifier GO_term References
GO:0006351TAS-transcription, DNA-dependent10761931
GO:0006355TAS-regulation of transcription, DNA-dependent10761931
GO:0007275TAS-multicellular organismal development10761931
GO:0009615IEP-response to virus-
GO:0045893IDA-positive regulation of transcription, DNA-dependent19805038
GO:0048304IEA-positive regulation of isotype switching to IgG isotypes-
GO:0050776IEA-regulation of immune response-
GO:0072676IDA-lymphocyte migration19805038
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
TBX21CREBBP10777717075044 Affinity Capture-Western
TBX21CREBBP11902717075044 Affinity Capture-Western
TBX21EP30010834717075044 Affinity Capture-Western
TBX21EP30011902717075044 Affinity Capture-Western
TBX21GATA310889517075044 Affinity Capture-Western
TBX21GATA311902717075044 Affinity Capture-Western
TBX21HOXC1111902720211142 Two-hybrid
TBX21HOXC1110946720211142 Two-hybrid
TBX21SP111902717075044 Affinity Capture-Western
TBX21SP111255017075044 Affinity Capture-Western
ZNF490TBX2111902720211142 Two-hybrid
ZNF490TBX2112154420211142 Two-hybrid
No data
No data
Genomic Variants Top
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:1888984
  • Data Attributes: MGI curated and HomoloGene calculated
MGI Allele ID Allele Symbol Allele Source Allele Type / Mutant Cell line ID
MGI:2180194Tbx21[tm1Glm]Allele from Mouse Targeted (knock-out)
  • tumorigenesis
  • nervous system phenotype
  • homeostasis/metabolism phenotype
  • endocrine/exocrine gland phenotype
  • digestive/alimentary phenotype
  • cardiovascular system phenotype
  • immune system phenotype
  • respiratory system phenotype
  • hematopoietic system phenotype
MGI:3664621Tbx21[tm1Srnr]Allele from Mouse Targeted (knock-out)
  • homeostasis/metabolism phenotype
  • immune system phenotype
  • hematopoietic system phenotype
MGI:4367995Tbx21[duane]Allele from Mouse Chemically induced (ENU)
  • immune system phenotype
  • hematopoietic system phenotype