AutismKB

Annotation Detail for GCLC


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Basic Information Top
Gene Symbol:GCLC ( GCL,GCS,GLCL,GLCLC )
Gene Full Name: glutamate-cysteine ligase, catalytic subunit
Band: 6p12
Quick LinksEntrez ID:2729; OMIM: 606857; Uniprot ID:GSH1_HUMAN; ENSEMBL ID: ENSG00000001084
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005737ISS-cytoplasm-
GO:0005829TAS-cytosol-
GO:0017109IEA-glutamate-cysteine ligase complex-
GO ID Evidence Qualifier GO_term References
GO:0000166IEA-nucleotide binding-
GO:0000287IDA-magnesium ion binding24639
GO:0004357IDA-glutamate-cysteine ligase activity11972604
GO:0004357IMP-glutamate-cysteine ligase activity16183645
GO:0005524IEA-ATP binding-
GO:0016595IDA-glutamate binding9841880
GO:0016874IEA-ligase activity-
GO:0043531IDA-ADP binding24639
GO:0046982IEA-protein heterodimerization activity-
GO:0050662IPI-coenzyme binding9675072
GO ID Evidence Qualifier GO_term References
GO:0006534IDA-cysteine metabolic process2294991
GO:0006536IDA-glutamate metabolic process12663448
GO:0006750IDA-glutathione biosynthetic process10395918
GO:0006750IMP-glutathione biosynthetic process12663448
GO:0006750TAS-glutathione biosynthetic process-
GO:0006805TAS-xenobiotic metabolic process-
GO:0006916IDA-anti-apoptosis10439045
GO:0006979IDA-response to oxidative stress10395918
GO:0009408IDA-response to heat8104187
GO:0009410IEA-response to xenobiotic stimulus-
GO:0009725IDA-response to hormone stimulus8104187
GO:0019852IEA-L-ascorbic acid metabolic process-
GO:0031397IEA-negative regulation of protein ubiquitination-
GO:0032436IEA-positive regulation of proteasomal ubiquitin-dependent protein catabolic process-
GO:0043524IEA-negative regulation of neuron apoptosis-
GO:0045454IDA-cell redox homeostasis10439045
GO:0045892IDA-negative regulation of transcription, DNA-dependent10439045
GO:0046685IEA-response to arsenic-containing substance-
GO:0050880IMP-regulation of blood vessel size12598062
GO:0051409IEA-response to nitrosative stress-
GO:0051900IEA-regulation of mitochondrial depolarization-
Protein-Protein Interaction Top
Genomic Variants Top
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:104990
  • Data Attributes: MGI curated and HomoloGene calculated
MGI Allele ID Allele Symbol Allele Source Allele Type / Mutant Cell line ID
MGI:2387010Gclc[tm1Mwl]Allele from Mouse Targeted (knock-out)
  • normal phenotype
  • growth/size phenotype
  • embryogenesis phenotype
  • cellular phenotype
MGI:2429419Gclc[tm1Dwn]Allele from Mouse Targeted (knock-out)
  • liver/biliary system phenotype
MGI:4432016Gclc[tm1e(EUCOMM)Wtsi]Mutant from cell lines23853
-
MGI:4432329Gclc[tm1a(EUCOMM)Wtsi]Mutant from cell lines23853
-