AutismKB

Annotation Detail for ATF6


View Evidences View Annotations
Basic Information Top
Gene Symbol:ATF6 ( ATF6A )
Gene Full Name: activating transcription factor 6
Band: 1q22-q23
Quick LinksEntrez ID:22926; OMIM: 605537; Uniprot ID:ATF6A_HUMAN; ENSEMBL ID: ENSG00000118217
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0000139TAS-Golgi membrane-
GO:0005634IEA-nucleus-
GO:0005635TAS-nuclear envelope10866666
GO:0005654TAS-nucleoplasm10866666
GO:0005783IEA-endoplasmic reticulum-
GO:0005789TAS-endoplasmic reticulum membrane-
GO:0016020IEA-membrane-
GO:0016021IEA-integral to membrane-
GO ID Evidence Qualifier GO_term References
GO:0003700IEA-sequence-specific DNA binding transcription factor activity-
GO:0003713TAS-transcription coactivator activity10866666
GO:0005515IPI-protein binding16469704
GO:0043565IEA-sequence-specific DNA binding-
GO:0046983IEA-protein dimerization activity-
GO ID Evidence Qualifier GO_term References
GO:0006351TAS-transcription, DNA-dependent10564271
GO:0006357TAS-regulation of transcription from RNA polymerase II promoter10564271
GO:0006457TAS-protein folding10564271
GO:0006950TAS-response to stress10866666
GO:0006986IEA-response to unfolded protein-
GO:0006990TAS-positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response9837962
GO:0007165TAS-signal transduction9271374
GO:0030968TAS-endoplasmic reticulum unfolded protein response19816510
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
ATF6CREB111658620936779 Two-hybrid
ATF6CREB110777520936779 Two-hybrid
ATF6ATF6B11658611158310 Two-hybrid
ATF6ATF6B10777811158310 Two-hybrid
ATF6GTF2I11658611287625 Affinity Capture-Western
ATF6GTF2I10922411287625 Affinity Capture-Western
ATF6NFYA11658611158310 Two-hybrid
ATF6NFYA11086611158310 Two-hybrid
ATF6NFYC11658611158310 20936779 Reconstituted Complex; Two-hybrid
ATF6NFYC11086811158310 20936779 Reconstituted Complex; Two-hybrid
ATF6SREBF211658614765107 Affinity Capture-Western; Reconstituted Complex
ATF6SREBF211259914765107 Affinity Capture-Western; Reconstituted Complex
ATF6SRF1165869271374 Reconstituted Complex; Two-hybrid
ATF6SRF1126009271374 Reconstituted Complex; Two-hybrid
ATF6YY111658610866666 15899857 Affinity Capture-Western; Reconstituted Complex
ATF6YY111336010866666 15899857 Affinity Capture-Western; Reconstituted Complex
ATF6ATF611658611158310 Two-hybrid
No data
No data
Genomic Variants Top
Variant ID Location Publication Method/platform Gain Lose Total Frequency Sample Size Genes
Variation_6791 chr1:159745305-160346951 17666407 Agilent 185k CGH Arrays/Agilent Custom CGH Arrays 1 34 35- 50 control samples (French) ATF6, DUSP12, RPL31P11, HSPA7, FCGR2A, FCGR2C, FCRLB, FCGR3B, FCGR2B, HSPA6, FCGR3A, FCRLA, OLFML2B, NOS1AP
No data
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:1926157
  • Data Attributes: MGI curated and HomoloGene calculated
MGI Allele ID Allele Symbol Allele Source Allele Type / Mutant Cell line ID
MGI:3655486Atf6[Gt2Wcs]Allele from Mouse Gene trapped
  • no phenotypic analysis
MGI:3723526Atf6[tm1.1Rjk]Allele from Mouse Targeted (knock-out)
  • liver/biliary system phenotype
  • homeostasis/metabolism phenotype
  • cellular phenotype
MGI:3839240Atf6[tm1Kamo]Allele from Mouse Targeted (Reporter)
  • cellular phenotype
No data
No data

Quick Search:


  (e.g. NLGN4X)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 616
  • Genes: 3,075
  • SNPs/VNTRs: 3,386
  • CNVs: 4,617
  • Linkage Regions: 158
  • Last Update: 05/25/2012
  • Click to Download Data

Registered with NIF